Callumae Supplement Facts
Learn more about the ingredients in Callumae.
Other Ingredients: Vegetarian Capsule (Hypromellose), Rice Powder, Magnesium Stearate
Daily Dosage: As a dietary supplement, take one capsule in the morning and one capsule in the afternoon with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.
Picrorhiza (Picrorhiza kurroa)- This medicinal plant has a long tradition of use for immune dysfunction in Ayurvedic medicine, which may be beneficial to patients with vitiligo (thought to have an autoimmune component) (1). Picrorhiza also assists with digestion and research has shown that as many as 6 compounds in Picrorhiza have anti-inflammatory activity, inhibiting the COX-2 enzyme (2,3). When combined with the vitiligo drug methoxsalen, picrorhiza improves the effectiveness of the treatment in restoring normal skin pigmentation (4).
Ginkgo biloba- Oxidative stress appears to play a role in the pathogenesis of vitiligo, making antioxidant compounds useful in the treatment of this disorder. Fortunately, compounds in gingko exert antioxidant and immunomodulatory effects. A double-blind, placebo controlled trial showed that an extract of gingko could arrest the progression of vitiligo and possibly assist with repigmentation (5). Patients with slow-spreading vitiligo experienced a halt in depigmentation, while some noticed marked to complete repigmentation.
Vitamin B-6- This essential vitamin plays a critical role in energy metabolism, nervous system function and immunity. Vitamin B6 is often given empirically for people with autoimmune disease. Research shows it is effective in treating skin disorders like acne vulgaris, polymorphic light eruption and seborrheic dermatitis (6). A topical preparation of vitamin B6 can strengthen the protective layer of the skin, the stratum corneum (7).
Vitamin B-12 and Folic Acid- A clinical study of patients with actively spreading vitiligo was conducted where subjects took a combination of vitamin B12, folate and vitamin C along with UVB treatments (8). The results showed that 100% of subjects had a halt in depigmentation, and induction of repigmentation in 6-8 weeks. Another study showed that the combination of vitamin B12, folic acid and sun exposure was more effective in inducing repigmentation than either of the treatments alone (9). As well, folic acid and B12 levels in serum are often lower in patients with vitiligo (10).
L-Phenylalanine- Clinical research shows that this amino acid produces good results in both children and adults with vitiligo, when combined with light therapy (16,17). A combination of oral and topical L-phenylalanine, sunlight or UVA and 0.025% clobetasol proprionate at night is especially effective for treatment of evolutive vitiligo on the face or in children, and is without side effects (18). Khellin encapsulated in L-phenylalanine stabilized liposomes shows dramatic results when combined with UVA (19). After 12 months of treatment, 75-100% repigmentation was observed on the face in 63% of subjects, on the back in 59%, arms in 58%, trunk in 57% and legs in 56%.
Lipoic Acid- A fat and water-soluble antioxidant, lipoic acid may be helpful for people with vitiligo, which appears to be related to oxidative stress (20). Research suggests that vitiligo is, in part, caused by poor antioxidant status, so supplementation with antioxidants like lipoic acid may improve the response to free radical production.
1. Picrorhiza kurroa. Alt Med Rev 2001 6(3):319-321.
2. Rastogi R et al. Hepatocurative effect of picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in rats. Planta Med 2000 Dec;66(8):709-13.
3. Zhang Y et al. Cyclooxygenase-2 enzyme inhibitory triterpenoids from Picrorhiza kurroa seeds. Life Sci 2005 Nov 4;77(25):3222-30. Epub 2005 Jun 23.
4. Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an Ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol 1989;27: pp.347-52
5. Parsad D, Pandhi R, Juneja A. Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo. Clin Exp Dermatol. 2003 May;28(3):285-7.
6. Snider B, Dietman DF. Pyridoxine therapy for premenstrual acne flare. Arch Dermatol 1974;110:130-131.
7. Draelos ZD, Ertel K, Berge C. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis 2005 Aug;76(2):135-41.
8. Draelos ZD, Ertel K, Berge C. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis 2005 Aug;76(2):135-41.
9. Don P et al. Treatment of vitiligo with broadband ultraviolet B and vitamins. Int J Dermatol 2006 Jan;45(1):63-5.
10. Juhlin L, Olsson MJ. Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure. Acta Derm Venereol 1997 Nov;77(6):460-2.
11. Montes LF et al. Folic acid and vitamin B12 in vitiligo: a nutritional approach. Cutis 1992 Jul;50(1):39-42.
12. Abdel-Fattah A, Aboul-Enein MN, Wassel GM, et al. An approach to the treatment of vitiligo by khellin. Dermatologicia. 1982;165:136–140.
13. Orecchia G, Sangalli ME, Gazzaniga A, et al. Topical photochemotherapy of vitiligo with a new khellin formulation: preliminary clinical results. J Dermatol Treat. 1998;9:65–69.
14. Hofer A, Kerl H, Wolf P. Long-term results in the treatment of vitiligo with oral khellin plus UVA. Eur J Dermatol 2001 May-Jun;11(3):225-9.
15. Valcova S, Trashlieva M, Christova P. Treatment of vitiligo with local khellin and UVA: comparison with systemic PUVA. Clin Exp Dermatol 2004 Mar;29(2):180-4.
16. Carlie G et al. KUVA (khellin plus ultraviolet A) stimulates proliferation and melanogenesis in normal human melanocytes and melanoma cells in vitro. Br J Dermatol 2003 Oct;149(4):707-17.
17. Siddiqui AH et al. L-Phenylalanine and UVA irradiation in the treatment of vitiligo. Phamacol Treat. 1994;188:215–18.
18. Schulpis CH et al. Phenylalanine plus ultraviolet light: preliminary report of a promising treatment for childhood vitiligo. Pediatr Dermatol. 1989;6:332–335.
19. Camacho F, Mazuecos J. Oral and topical L-phenylalanine, clobetasol propionate, and UVA/sunlight--a new study for the treatment of vitiligo. J Drugs Dermatol 2002 Sep;1(2):127-31.
20. De Leeuw J et al. A case study to evaluate the treatment of vitiligo with khellin encapsulated in L-phenylalanin stabilized phosphatidylcholine liposomes in combination with ultraviolet light therapy. Eur J Dermatol 2003 Sep-Oct;13(5):474-7.
21. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
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*Callumae is a Vitiligo Remedy designed to help get rid of white spots on your skin. Use in conjunction with light therapy (or natural sun light) to help get the most repigmentation to your skin.