Moderex Supplement Facts

Daily Dosage: As a dietary supplement, take one capsule 30 minutes before bedtime.

Moderex Research:

Inositol - is essential for the proper functioning of several brain neurotransmitters, including serotonin and acetylcholine. In clinical studies, inositol has been reported to be useful in treating depression and panic disorder (1, 2).

Valerian Root - has traditionally been used in folk medicine as a sedative to soothe anxiety and treat insomnia. Clinical studies have shown that supplementation with valerian root may improve sleep quality and relieve insomnia (3-5).

GABA (Gamma Amino Butyric Acid) - is an amino acid involved in calming neurotransmitter activity in the brain. Studies suggest that GABA supplementation relieves stress and anxiety, and calms the mind and body (6, 7).

Lupulin (Hops,pollen) - has been used for millennia as a mild sedative and to soothe anxiety. It has been shown to be a central nervous system depressant (10).
 

Glutamic Acid - is an essential neurotransmitter in the central nervous system and a precursor to GABA, another ingredient in Moderex (11).

Magnesium (amino acid chelate) - is involved in many vital body functions including transmission of nerve impulses and muscle contractions. It has been reported to relieve tension headaches and dysmenorrhea (premenstrual mood changes) (12, 13).

Niacinamide - is a form of vitamin B3 (also called nicotinamide) used to support nervous system health (14).

Passion Flower - has traditionally been used by the Aztecs to relieve anxiety and treat insomnia. Passion flower is synergistic with other ingredients in Moderex, including valerian (15).

Thiamine HCL - Also known as vitamin B1, thiamine is essential for nerve and tissue function, energy production in the brain, and the proper functioning of the brain neurotransmitter, acetylcholine (16).

5-Hydroxy Tryptophan - is a neurotransmitter in the brain that regulates our moods and sleeping patterns, and is a precursor for serotonin and melatonin. In clinical studies, 5-hydroxy tryptophan (5-HTP) has been shown to be effective in treating anxiety, depression, and insomnia (17-19).

Moderex References:

1. Benjamin J, et al. Inositol treatment in psychiatry. Psychopharmacol Bull 1995; 31 (1): 167-175.

2. Levine J, et al. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry 1995; 152:792-794.

3. Balderer G, Borbely AA. Effect of valerian on human sleep. Psychopharmacol 1985; 87:406-9.

4. Leathwood PD, et al. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav 1982; 17:65-71.

5. Lindahl O, Lindwall L. Double blind study of a valerian preparation. Pharmacol Biochem Behav 1989; 32(4):1065-6.

6. Krystal JH, Sanacora G, et al. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Mol Psychiatry. 2002;7 Suppl 1:S71-80.

7. Sanacora G et al. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry. Jul2004;61(7):705-13.

8. Kinzler E et al. Clinical efficacy of a kava extract in patients with anxiety syndrome: double-blind placebo controlled study over 4 weeks. Arzneim Forsch 1991;41:548-8.

9. Warnecke G. [Psychosomatic dysfunctions in the female climacteric. Clinical effectiveness and tolerance of Kava Extract WS 1490] Fortschr Med. 1991 Feb 10;109(4):119-22.

10. Hansel R, et al. Sedative-hypnotic compounds i the exhalation of hops, II. Z Naturforsch (C) Dec1980;35(11-12):1096-97.

11. Balch James F. and Phyllis A., Prescription for Nutritional Healing, 3rd ed., New York, NY: Penguin Putnam Avery, 2000: 38

12. Facchinetti F et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol Aug 1991;78(2):177-81.

13. Mauskop A et al. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci 1998;5(1):24-7.

14. Balch James F. and Phyllis A., Prescription for Nutritional Healing, 3rd ed., New York, NY: Penguin Putnam Avery, 2000: 15.

15. Bourin M et al. A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study versus placebo. Fundam Clin Pharmacol 1997;11(2):127-32.

16. Benton D et al. The impact of long-term vitamin supplementation on cognitive functioning. Psychopharmacol 1995;117:298-305.

17. Kahn RS et al. L-5-hydroxytryptophan in the treatment of anxiety disorders. J Affect Disord Mar1985;8(2):1970-200

18. van Praag H et al. Depression vlunerability and 5-hydroxytryptophan prophylaxis. Psychiatry Res Sep1980;3(1):75-83.

19. Poldinger W et al. Functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology. 1991;24(2):53-81.