Daily Dosage: As a dietary supplement, take one capsule in the morning and one capsule in the afternoon with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.

Prenox D7 Research:

Vitamin A - Those who are HIV positive or have AIDS excrete substantially more Vitamin A in their urine, making them deficient in this Vitamin. In women, low Vitamin A levels have shown to increase the mother-to-child transmission of HIV during pregnancy. (1)

Vitamin B1 - This is a very important vitamin for those diagnosed with AIDS. Vitamin B1 deficiencies often occur in AIDS patients and over time cause brain damage. (15)

Vitamin B12 - Frequent problems with digestion in HIV-positive individuals can lead to Vitamin B12 deficiency. Vitamin B12 levels have also been shown to decline as the disease progresses. Supplementing B12 may be helpful in avoiding anemia an other neurological symptoms. (2)

Vitamin C - Vitamin C has been shown to help suppress the replication of the HIV virus and also protects the brain in the later stages of AIDS. (3) It is also a very important factor to help support the immune system.

Vitamin E - An important antioxidant that may slow down the progression of AIDS by adding back deficiencies. (4) Signs are showing that Vitamin E can help anti-HIV drugs work more effectively. (5)

Selenium - Deficiencies are caused by the HIV virus because it utilizes Selenium for metabolic purposes. Your immune system needs Selenium to function properly, therefore, supplementing this back into your diet may be helpful. (6)

Zinc - Zinc is important to support immune function. AIDS medications may deplete zinc levels. Studies show that zinc can stabilize body weight, raise the number of T4 cells, and reduce infections. (7)

Beta Carotene - Can improve T4 cell function and increase T4 counts. Beta-Carotene deficiency is common in all stages of HIV and AIDS. (8)

L-Glutamine - Has been shown to have the following benefits with those who have AIDS: 1) Strengthens membrane linings in the intestinal tract, 2) Slows the breakdown of muscle tissue, 3) Stimulates the immune system. (12, 13, 14)

Milk Thistle Ext. - Can help protect the liver from free radicals and toxins by providing flavonoids known as "silymarin." (21, 22,23 )

Betaine - Used to help with digestive processes by facilitating the conversion of pepsinogen to pepsin, which is essential for proper digestion of protein.

Reishi Mushroom - Called the "mushroom of immortality" in China. This mushroom supports the immune system, promotes memory, and lengthens life span. (17)

Shitake Mushroom - Supports the immune system by activating T helper cells, increasing the number of B cells, boosting antibody production, and reinforcing immune substances. (18,19)

N-Acetyl Cysteine HCI - Have been found to be deficient in blood tests from AIDS patients. This nutrient is important because is helps the body produce "glutathione" which is a protein used by the liver to inhibit toxins. (10) In a recent study AIDS patients who took N-Acetyl Cysteine lived twice as long as those who did not. (11)

Beta Sitoserol - Has been shown to support the immune system and modulate the functions of T-cells. (16)

L-Carnitine HCI - Studies suggest this may improve immune function. (9)

Olive Leaf Ext. - An effective antimicrobial agent against a wide variety of bacterias including, Salmonella, Staph aureus, and E. Coli. (20)

Coenzyme Q100 - An important antioxidant that supports the immune system.

References:

1. Semba RD. Maternal vitamin A deficiency and mother-to-child transmission of HIV-1. Lancet. Jun1994;343(8913):1593-7.

2. Ramacha AF, Cadafalch J. Cobalamin deficiency in patients infected with the human immunodeficiency virus. Semin Hematol. Jan1999;36(1):75-87.

3. Everall IP, et al. Decreased absolute levels of ascorbic acid and unaltered vasoactive intestinal polypeptide receptor binding in the frontal cortex in acquired immunodeficiency syndrome. Neurosci Lett. Mar1997;224(2):119-22.

4. Jordao Junior AA, et al. Urinary excretion and plasma vitamin E levels in patients with AIDS. Nutrition. May1998;14(5):423-6.

5. Odeleye OE, Watson RR. The potential role of vitamin E in the treatment of immunologic abnormalities during acquired immune deficiency syndrome. Prog Food Nutr Sci. 1991;15(1-2):1-19.

6. Patrick L. Nutrients and HIV: part one - beta carotene and selenium. Altern Med Rev. Dec1999;4(6):403-13.

7. Mocchegiani E, et al. Benefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS. Int J Immunopharmacol. Sep1995;17(9):719-27.

8. Fryburg DA, et al. The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: a pilot study. Yale J Biol Med. Jan1995;68(1-2):19-23.

9. DeSimone C, et al. High dose L-carnitine improves immunologic and metabolic parameters in AIDS patients. Immunopharmacol Imunnotoxicol. 1993;15(1):1-12.

10. Droge W. Cysteine and glutathione deficiency in AIDS patients: a rationale for the treatment with N-acetyl-cysteine. Pharmacology. 1993;46(2):61-5.

11. Herzenberg LA, DeRosa SC, Dubs JG, et al. Glutathione deficiency is associated with impaired survival in HIV disease. Proc Natl Acad Sci USA. 1967-1972,1997:94.

12. Wells SM, et al. Dietary glutamine enhances cytokine production by murine macrophages. Nutrition. Nov1999;15(11-12):881-4.

13. Gismondo MR, Drago L, Fassina MC, et al. Immunostimulating effect of oral glutamine. Dig Dis Sci. 1998;43:1752-1754.

14. van der Hulst RR, von Meyenfeldt MF, Tiebosch A, et al. Glutamine and intestinal immune cells in humans. JPEN J Parenter Enteral Nutr. 1997;21:310-315.

15. Butterworth RF, et al. Thiamine deficiency and Wernicke's encephalopathy in AIDS. Metab Brain Dis. Dec1991;6(4):207-12.

16. Plat J, Kerckhoffs DA, Mensink RP. Therapeutic Potential of Plant Sterols and Stanols. Curr Opin Lipidol. Dec2000;11(6):571-6.

17. Jong SC, et al. Medicinal Benefits of the Mushroom Ganoderma. Adv Appl Microbiol. 1992;37:101-34.

18. Suzuki H, et al. Immunopotentiating Substances in Lentinus edodes Mycelial Extract (LEM) - Activation of Macrophage and Proliferation of Bone Marrow Cell. Nippon Shokakibyo Gakkai Zasshi. Jul1988;85(7):1430.

19. Suzuki H, et al. Inhibition of the Infectivity and Cytopathic Effect of Human Immunodeficiency Virus by Water-soluble Lignin in an Extract of the Culture Medium of Lentinus edodes Mycelia (LEM). Biochem Biophys Res Commun. Apr1989;160(1):367-373.

20. Bisignano G, et al. On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. J Pharm Pharmacol. Aug1999;51(8):971-4.

21. Flora K, et al. Milk Thistle (Silybum marianum) for the Therapy of Liver Disease. Am J Gastroenterol. 1998;93(2):139-43.

22. Salmi H, et al. Effect of Silymarin on Chemical, Functional, and Morphological Alterations of the Liver. A Double-blind Controlled Study. Scand J Gastroent. 1982;17:517-21.

23. Wichtl M, in NA Bissett, ed. Herbal Drugs and Phytopharmaceuticals. Stuttgart: Scientific Press; 1994:121-23.