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Resterol Supplement Facts
Learn more about the ingredients in Resterol.
Daily Dosage: As a dietary supplement, take one capsule in the morning and two capsules in the evening with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.
Vitamin E - A potent antioxidant, vitamin E has been studied and used for years to improve cardiovascular health. The risk of having high cholesterol is the formation of atherosclerotic plaques in the coronary arteries. A six year study of men and women smokers and nonsmokers with high cholesterol showed that taking vitamin E and C can slow the progression of atherosclerosis (1). Another randomized clinical study in men with high cholesterol showed that vitamin E taken on its own, long term, reduces peroxidation of lipids, like cholesterol, which is a major factor in the process of forming atherosclerotic plaques (2). Vitamin E supplementation also appears to reverse levels of certain molecules (VCAM-1 and nitric oxide) in the blood that contribute to atherosclerosis in people with high cholesterol (3).
Pantethine - The effect of supplementation on cardiovascular health with this B vitamin has been known for many years. Researchers gave diabetics pantethine for 9 months and observed reductions in plasma triglyceride, total cholesterol, apo E and apo CII levels (4). More recent animal research has shown that administration of panthothenic acid derivatives including pantethine lowered food intake, mean body weight, insulin and glucose levels and decreased the content of triglycerides, total cholesterol and cholesterol esters in serum and adipose tissue (5). It appears the positive effects of pantethine in lowering lipids are related to its effect on insulin.
Garlic (Allium sativa) - This botanical medicine, often referred to as the panacea of herbs, is very useful in cardiovascular disease. A double-blind placebo controlled study of patients with mild to moderate hypercholesterolemia, revealed that garlic can help lower total and LDL cholesterol levels and can be even more effective when combined with dietary changes (6). Certain compounds in garlic have demonstrated the ability to reduce oxidation of LDL cholesterol, which contributes to atherosclerosis (7).
Turmeric extract (Curcuma longa) - Known widely for its use in Indian cuisine, turmeric is a powerful antioxidant with clinical applications in cardiovascular disease and cancer. One of the active components in turmeric is curcumin. Research shows that curcumin can lower cholesterol levels due to an effect on cholesterol absorption, degradation or elimination (8). Very recently, researchers discovered that curcumin appears to work on a molecular level, regulating genes involved in cholesterol metabolism (9).
Inositol - A form of inositol called inositol hexaphosphate is another strong antioxidant. Animal research shows that supplementation significantly lowers elevated levels of serum total cholesterol, triglycerides and zinc/copper ratio associated with administration of the cholesterol-enriched diet (10).
Gum Guggul Extract (Commiphora mukul) - Classically used in Ayurvedic medicine to lower cholesterol, gum guggul has received much interest in the Western world. Research supports the use of guggul to lower high levels of lipids. When compared to placebo, guggul given for 24 weeks in combination with a diet rich in fruits and vegetables, demonstrated the ability to decrease the total cholesterol level by 11.7%, the LDL level by 12.5%, triglycerides by 12.0%, and the total cholesterol/high density lipoprotein (HDL) cholesterol ratio by 11.1%. (11). Furthermore, the combined effect of diet and guggul at 36 weeks was as great as the reported lipid-lowering effect of modern drugs. While there are some conflicting results, there are numerous studies supporting the cholesterol lowering effect of guggul (12).
Policosanol - Administration of policosanol has been shown to lower cholesterol in some studies, although there is one recent study that suggests when given alone it may not be effective. However, when used in combination with omega 3 fatty acids, LDL-C was significantly reduced by 21.1% and 24.4% depending on the dose of policosanol (5mg or 10 mg, respectively) (13). Total cholesterol and HDL levels were also improved with this combination therapy. A pilot study also showed that policosanol (10 mg/day) was slightly more effective than lovastatin (20 mg/day) in reducing the LDL-C/HDL-C and total cholesterol/HDL-C ratios, in increasing HDL-C levels and in preventing LDL oxidation (14).
1. Salonen RM et al. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation 2003 Feb 25;107(7):947-53.
2. Kaikkonen J et al. Supplementation with vitamin E but not with vitamin C lowers lipid peroxidation in vivo in mildly hypercholesterolemic men. Free Radic Res 2001 Dec;35(6):967-78.
3. Desideri G et al. Vitamin E supplementation reduces plasma vascular cell adhesion molecule-1 and von Willebrand factor levels and increases nitric oxide concentrations in hypercholesterolemic patients. J Clin Endocrinol Metab 2002 Jun;87(6):2940-5.
4. Eto M et al. Lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus. Artery 1987;15(1):1-12.
5. Naruta E, Buko V. Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose. Exp Toxicol Pathol 2001 Oct;53(5):393-8.
6. Kannar D et al. Hypocholesterolemic effect of an enteric-coated garlic supplement. J Am Coll Nutr 2001 Jun;20(3):225-31.
7. Lau BH. Suppression of LDL oxidation by garlic. J Nutr 2001 Mar;131(3s):985S-8S.
8. Arafa HM. Curcumin attenuates diet-induced hypercholesterolemia in rats. Med Sci Monit 2005 Jul;11(7):BR228-234. Epub 2005 Jun 29.
9. Peschel et al. Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr Biochem 2006 May 16; [Epub ahead of print]
10. Jariwalla RJ. Inositol hexaphosphate (IP6) as an anti-neoplastic and lipid-lowering agent. Anticancer Res 1999 Sep-Oct;19(5A):3699-702.
11. Singh RB et al. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994 Aug;8(4):659-64.
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Resterol is a natural remedy that promotes healthy cholesterol levels. Works best when used in conjuction with a healthy diet such as the Paleo Diet.