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Sedorum Interactions

Medications That May Interact with Sedorum.
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 Sedorum Interactions

 Serving Size:  4 Capsules
 Servings Per Container:  30



  Amount
Per Serving
Daily Value


  Folic Acid 5000 mcg 1250%

  Vitamin B12 (Cyanocobalamin) 25 mcg 416%

  Calcium (as Calcium Gluconate) 50 mg 5%

  Iron (as Amino Acid Chelate) 25 mg 139%

  Magnesium (as Magnesium Oxide) 175 mg 44%




  Valerian Extract (Valeriana officinalis) (root) 250 mg *

  Lemon Balm Extract (Melissa officinalis) (leaf) 50 mg *

  GABA Powder 1500 mg *

  Glycine 500 mg *


   Other Ingredients:  Gelatin, Rice Powder, Magnesium Stearate.
   *Daily Value Not Established



Daily Dosage: As a dietary supplement, take two capsules in the morning and two capsules in the evening with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.  

 

Sedorum Research:

Possible Interactions with: Folic Acid
Also listed as: Folacin; Folate; Folic Acid; Vitamin B9 (Folic Acid)

If you are currently being treated with any of the following medications, you should not use folic acid supplements without first talking to your healthcare provider.

Antibiotics, Tetracycline - Folic acid should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Folic acid either alone or in combination with other B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

In addition, long-term use of antibiotics can deplete vitamin B levels in the body, particularly B2, B9, B12, and vitamin H (biotin), which is considered part of the B complex.

Aspirin, Ibuprofen, and Acetaminophen - When taken for long periods of time, these medications, as well as other anti-inflammatories can increase the body's need for folic acid.

Birth Control Medications, Anticonvulsants, and Cholesterol-lowering Medications - Birth control medications, anticonvulsants for seizures (namely, phenytoin and carbamazapine), and cholesterol-lowering medications (namely, bile acid sequestrants including cholestyramine, colestipol, and colesevelam) may reduce the levels of folic acid in the blood as well as the body's ability to use this vitamin. Extra folate when taking any of these medications may be recommended by your healthcare provider. When taking bile acid sequestrants for cholesterol, folate should be taken at a different time of day.

Sulfasalazine - Sulfasalazine, a medication used for ulcerative colitis and Crohn's disease, may reduce the absorption of folic acid, leading to lower levels of folic acid in the blood.

Methotrexate - Methotrexate, a medication used to treat cancer and rheumatoid arthritis, increases the body's need for folic acid. Folic acid reduces the side effects of methotrexate without decreasing its effectiveness.

Other - Antacids, cimetidine, and ranitidine (used for ulcers, heartburn, and related symptoms) as well as metformin (used for diabetes) may inhibit the absorption of folic acid. It is best, therefore, to take folic acid at a different time from any of these medications.

Barbiturates, such as pentobarbital and phenobarbital, used for seizures, may impair folic acid metabolism.


Possible Interactions with: Vitamin B12 (Cyanocobalamin)
Also listed as: Cobalamin; Cyanocobalamin; Vitamin B12 (Cobalamin)

If you are currently being treated with any of the following medications, you should not use vitamin B12 supplements without first talking to your healthcare provider.

Antibiotics, Tetracycline - Vitamin B12 should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Vitamin B12 either alone or in combination with other B vitamins should be taken at different times of the day from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

In addition, long-term use of antibiotics can deplete vitamin B levels in the body, particularly B2, B9, B12, and vitamin H (biotin), which is considered part of the B complex.

Anti-ulcer Medications - The body's ability to absorb vitamin B12 is decreased when taking stomach acid-reducing medications such as omeprazole, lansoprazole, ranitidine, cimetidine, or antacids that are often used to treat gastroesophageal reflux, ulcers or related symptoms. This interference is most likely to occur as a result of prolonged use (more than one year) of these medications.

Chemotherapy Medications - Blood levels of vitamin B12 may be reduced when taking chemotherapy medications (particularly methotrexate) for cancer.

Metformin for diabetes - Blood levels of vitamin B12 may also be reduced when taking metformin for diabetes.

Phenobarbital and Phenytoin - Long-term treatment with either phenobarbital and phenytoin for seizure disorders may interfere with the body's ability to use vitamin B12.


Possible Interactions with: Calcium (as Calcium Gluconate)
Also listed as: Calcium

If you are currently being treated with any of the following medications, you should not use calcium supplements without first talking to your healthcare provider

Alendronate - Calcium may interfere with the absorption of alendronate, a medication used to treat osteoporosis. Calcium containing products, therefore, should be taken at least two hours before or after alendronate.

Antacids, Aluminum-containing - When calcium citrate is taken with aluminum containing antacids, the amount of aluminum absorbed into the blood stream may be increased significantly. This is a particular problem for people with kidney disease in whom the aluminum levels may become toxic. In addition, aluminum-containing antacids may increase the loss of calcium in the urine.

Blood Pressure Medications - Taking calcium with a beta-blocker (such as atenolol), a group of medications used for the treatment of high blood pressure or heart disorders, may interfere with blood levels of both the calcium and the beta-blocker. Study results are conflicting, however. Until more is known, individuals taking atenolol, or another beta blocker, should have their blood pressure checked before and after adding calcium supplements or calcium containing antacids to their medication regimen.

Similarly, it has been reported that calcium may reverse the therapeutic effects as well as the side effects of calcium channel blockers (such as verapamil) often prescribed for the treatment of high blood pressure. These study results are also controversial. People taking verapamil or another calcium channel blocker along with calcium supplements should likely have their blood pressure checked regularly.

Cholesterol-lowering Medications - A class of medications known as bile acid sequestrants (including cholestyramine, colestipol, and colesevelam), used to treat high cholesterol, may interfere with normal calcium absorption and increase the loss of calcium in the urine. Supplementation, therefore, with calcium and vitamin D may be recommended by your healthcare provider.

Corticosteroids - Corticosteroid medications reduce the absorption of calcium, thereby increasing the risk for bone loss and osteoporosis over time. This is of particular concern for anyone who is maintained on long-term steroids.

Digoxin - High levels of calcium may increase the likelihood of a toxic reaction to digoxin, a medication used to treat irregular heart rhythms. On the other hand, low levels of calcium cause this medication to be ineffective. People who are taking digoxin should have calcium levels monitored in the blood closely.

Diuretics - Two different classes of diuretics interact with calcium in opposite ways—thiazide diuretics such as hydrochlorothiazide can raise calcium levels in the blood, while loop diuretics, such as furosemide and bumetanide, can decrease calcium levels. In addition, amiloride, a potassium-sparing diuretic, may decrease the amount of calcium excreted in the urine (and subsequently increase calcium levels in the blood), especially in people with kidney stones.

Estrogens - Estrogens may contribute to an overall increase in calcium blood levels. Taking calcium supplements together with estrogens improves gain in bone density significantly.

Gentamicin - Taking calcium during treatment with the antibiotic gentamicin may increase the potential for toxic effects on the kidneys.

Metformin - Metformin, a medication used to treat type 2 diabetes, can deplete levels of vitamin B12. Some early evidence suggests that calcium supplements may prevent or eliminate this negative effect of metformin. More research is needed.

Antibiotics, Quinolones - Calcium can interfere with the body's ability to absorb quinolone antibiotics (such as ciprofloxacin, levofloxacin, norfloxacin, and ofloxacin). If taking calcium containing supplements or antacids, therefore, you should take them two to four hours before or after taking quinolone antibiotics.

Seizure Medications - Low levels of calcium have been reported with high doses of seizure medications, such as phenytoin, which may decrease calcium absorption. Some physicians recommend vitamin D along with anti-seizure drugs to try to prevent the development of low calcium levels.

Tetracyclines - Calcium can interfere with the body's ability to absorb tetracycline medications (including doxycycline, minocycline, and tetracycline) and, therefore, diminish their effectiveness. Calcium containing supplements and antacids should be taken at least two hours before or after taking these drugs.
 


Possible Interactions with: Iron (as Amino Acid Chelate)
Also listed as: Ferrous Sulfate; Iron

If you are currently being treated with any of the medications discussed below, you should not use iron without first talking to your healthcare provider.

Iron may interfere with the absorption of many different medications. For this reason, it is best to take iron supplements at least two hours before or two hours after taking medications. This is particularly true for the medications listed below.

The following medications may reduce the absorption of iron:

  • Cholestyramine and Colestipol: These are two cholesterol-lowering medications known as bile acid sequestrants.
  • Medications used to treat ulcers or other stomach problems : Examples of anti-ulcer medications include cimetidine, ranitidine, famotidine, and nizatidine. These medications belong to a class of drugs known as H2 receptor blockers. They change the pH in the stomach and subsequently alter the absorption of iron. It is possible that this effect could occur with other antiulcer medications including antacids and proton pump inhibitors (such as omeprazole and lansoprazole).

Iron decreases the absorption of the following medications:

  • Tetracyclines : These are a class of antibiotics that include doxycycline, minocycline, and tetracycline.
  • Quinolones : These are a class of antibiotics that include ciprofloxacin, norfloxacin, ofloxacin, and levofloxacin.
  • ACE inhibitors : These are a class of medications used to treat high blood pressure. Examples include captopril, enalapril, and lisinopril.

Iron may reduce the effectiveness or blood levels of the following medications:

  • Carbidopa and Levodopa : Iron lowers blood levels of these medications but it is unclear whether these changes lower the effectiveness of the drugs.
  • Levothyroxine : Iron may decrease the effectiveness of this thyroid replacement hormone. A healthcare practitioner should monitor thyroid function closely in those taking iron supplements with thyroid medications.

Iron levels may be increased by:

  • Birth control medications  

Possible Interactions with: Magnesium (Oxide)
Also listed as: Magnesium

If you are currently being treated with any of the following medications, you should not use magnesium without first talking to your healthcare provider.

Antibiotics - The absorption of quinolone antibiotics (such as ciprofloxacin and moxofloxacin), tetracycline antibiotics (including tetracycline, doxycycline, and minocycline), and nitrofurantoin is diminished when taken with magnesium supplements. Therefore, magnesium should be taken two to four hours before or after taking these medications to avoid interference with absorption.

Blood Pressure Medications, Calcium Channel Blockers - Magnesium may increase the likelihood of negative side effects (such as dizziness, nausea, and fluid retention) from calcium channel blockers (particularly nifedipine) in pregnant women. Other calcium channel blockers include amlodipine, diltiazem, felodipine, and verapamil.

Diabetic Medications - Magnesium hydroxide, commonly found in antacids, may increase the absorption of glipizide and glyburide, medications used to control blood sugar levels. Ultimately, this may prove to allow for reduction in the dosage of those medications.

Digoxin - It is important that normal levels of magnesium be maintained while taking digoxin because low blood levels of magnesium can increase adverse effects from this drug. In addition, digoxin can lead to increased loss of magnesium in the urine. A healthcare provider will follow magnesium levels closely to determine whether magnesium supplementation is necessary.

Diuretics - Two types of diuretics known as loop (such as furosemide) and thiazide (including hydrochlorothiazide) can deplete magnesium levels. For this reason, physicians who prescribe diuretics may consider recommending magnesium supplements as well.

Hormone Replacement Therapy for menopause - Magnesium levels tend to decrease during menopause. Studies suggest, however, that hormone replacement therapy may help prevent the loss of this mineral. Postmenopausal women or those taking hormone replacement therapy should talk with a healthcare provider about the risks and benefits of magnesium supplementation.

Levothyroxine - There have been case reports of magnesium containing antacids reducing the effectiveness of levothyroxine, which is taken for an under active thyroid. This is important because many people take laxatives containing magnesium without letting their doctor know.

Penicillamine - Penicillamine, a medication used for the treatment of Wilson's disease (a condition characterized by high levels of copper in the body) and rheumatoid arthritis, can inactivate magnesium, particularly when high doses of the drug are used over a long period of time. Even with this relative inactivation, however, supplementation with magnesium and other nutrients by those taking penicillamine may reduce side effects associated with this medication. A healthcare practitioner can determine whether magnesium supplements are safe and appropriate if you are taking penicillamine.

Tiludronate and Alendronate - Magnesium may interfere with absorption of tiludronate, a medication similar to alendronate that is used for the treatment of osteoporosis. This interaction has not been reported with alendronate specifically. Magnesium supplements or magnesium-containing antacids should be taken at least two hours before or two hours after taking these medications to minimize potential interference with absorption.

Others - Aminoglycoside antibiotics (such as gentamicin and tobramycin), thiazide diuretics (such as hydrochlorothiazide), loop diuretics (such as furosemide and bumetanide), amphotericin B, corticosteroids, antacids, and insulin may lower magnesium levels. Please refer to the depletions monographs on some of these medications for more information.


Possible Interactions with:  Valerian Extract (Valeriana officinalis) (root)
Also listed as: Valerian; Valeriana officinalis

If you are currently being treated with any of the following medications, you should not use valerian without first talking to your healthcare provider.

Anesthesia - For those facing surgery, it is important to note that valerian may increase the effects of anesthesia and, thus, it is important to discuss the use of valerian with your healthcare providers (particularly the surgeon and anesthesiologist) well in advance of your planned operation. The doctors may advise you on how to taper use of valerian prior to the surgery. Or, they may allow you to continue use up to the time of surgery, making any necessary adjustments to the anesthesia and giving you medication to avoid possible withdrawal symptoms from the valerian while in the hospital.

Sedatives and Anti-anxiety Medications - There are no reports in the scientific literature to suggest that valerian interacts with any conventional medications. However, valerian is a sedative herb that may increase the effects of alcohol and medications for anxiety and insomnia. Valerian should not be combined with barbiturates (medications, such as pentobarbital, prescribed for sleep disorders or seizures), and should be used with caution, if at all, by people taking benzodiazepines (anti-anxiety and sleep inducing medications including alprazolam, diazepam, and lorazepam) or other sedative medications (such as antihistamines).

 


 

Possible Interactions with: Lemon Balm Extract (Melissa officinalis) (leaf)
Also listed as: Balm leaves; Lemon Balm; Melissa; Melissa officinalis

Sedatives, Thyroid medications - Although it has not yet been demonstrated in clinical studies, lemon balm may interfere with sedatives and thyroid medications. If you are taking sedatives (for sleep disorders or anxiety) or medications to regulate your thyroid, you should consult a healthcare practitioner before taking lemon balm. 
 

Possible Interactions with: GABA Powder

We are unaware of any interactions with this supplement.


Possible Interactions with:  Glycine

We are unaware of any interactions with this supplement.


 

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