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Thyax Interactions

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Drugs that may interact with the ingredients in Thyax.

Thyax Interactions

Serving Size:  4 Capsules
Servings Per Container:  30


  Amount
Per Serving
Daily Value


   Vitamin B1 (thiamine HCl) 30 mg 2000%

   Vitamin B2 (riboflavin) 50 mg 2941%

   Vitamin B3 (niacin) 50 mg 250%

   Vitamin B6 (Pyridoxine HCL) 25 mg 1250%

   Folic Acid 400 mcg 100%

   Vitamin B12 (Cyanocobalamin) 50 mcg 833%

   Vitamin B5 (d-Calcium Pantothenate) 50 mg 500%

   Iodine (Kelp) 450 mcg 300%

   Magnesium (Oxide) 200 mg 50%

   Zinc (Oxide) 10 mg 67%

   Selenium (Sodium Selenite) 200 mcg 280%

   Copper (Gluconate) 100 mcg 5%

   Manganese (Citrate) 10 mg 500%

   Molybdenum  (as Sodium Molybdate) 50 mcg 67%



   Acetyl L-Tyrosine 1000 mg *

   L-Phenylalanine 200 mg *


Other Ingredients: Gelatin, Rice Powder, Magnesium Stearate.
   *Daily Value Not Established


Daily Dosage: As a dietary supplement, take two capsules in the morning and two capsules in the evening with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.  

Thyax Research:

Possible Interactions with:  Vitamin B1 (thiamine HCl)

Also listed as: Thiamine; Vitamin B1 (Thiamine)

If you are currently being treated with any of the following medications, you should not use vitamin B1 without first talking to your healthcare provider.

Antibiotics, Tetracycline - Vitamin B1 should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Vitamin B1 either alone or in combination with other B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

Antidepressant Medications, Tricylic - Taking vitamin B1 supplements may improve treatment with antidepressants such as nortriptyline, especially in elderly patients. Other medications in this class of antidepressants include desimpramine and imipramine.

Chemotherapy - Although the significance is not entirely clear, laboratory studies suggest that thiamine may inhibit the anti-cancer activity of chemotherapy agents. How this will ultimately prove relevant to people is not known. However, it may be wise for people undergoing chemotherapy for cancer to not take large doses of vitamin B1 supplements.

Digoxin - Laboratory studies suggest that digoxin (a medication used to treat heart conditions) may reduce the ability of heart cells to absorb and use vitamin B1; this may be particularly true when digoxin is combined with furosemide (a loop diuretic).

Diuretics - Diuretics (particularly furosemide, which belongs to a class called loop diuretics) may reduce the levels of vitamin B1 in the body. In addition, similar to digoxin, furosemide may diminish the heart's ability to absorb and utilize vitamin B1, especially when these two medications are combined.

Scopolamine - Vitamin B1 may help reduce some of the side effects associated with scopolamine, a medication commonly used to treat motion sickness. 


Possible Interactions with: Vitamin B2 (riboflavin)

Also listed as: Riboflavin; Vitamin B2 (Riboflavin)

If you are currently being treated with any of the following medications, you should not use vitamin B2 supplements without first talking to your healthcare provider.

Antibiotics, Tetracycline - Riboflavin should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Riboflavin either alone or in combination with other B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

In addition, long-term use of antibiotics can deplete vitamin B levels in the body, particularly B2, B9, B12, and vitamin H (biotin), which is considered part of the B complex.

Antidepressant Medications - Tricyclic antidepressants (such as imipramine, desimpramine, amitriptyline, and nortriptyline) also reduce levels of riboflavin in the body. Taking riboflavin may improve levels of the vitamin and improve the effectiveness of these antidepressants, especially in elderly patients.

Anti-malarial Medications - Riboflavin may reduce the effectiveness of anti-malarial medications such as chloroquine and mefloquine.

Antipsychotic Medications - Antipsychotic medications called phenothiazines (such as chlorpromazine) may lower riboflavin levels.

Birth Control Medications - Poor dietary habits in combination with birth control medications can interfere with the body's ability to use riboflavin.

Doxorubicin - In the presence of daylight, riboflavin may deactivate doxorubicin, a medication used for the treatment of certain cancers. In addition, doxorubicin may deplete levels of riboflavin and, therefore, increased amounts of this nutrient may be recommended during chemotherapy using this drug. Your doctor will guide you on whether this is necessary or not.

Methotrexate - Methotrexate, a medication used to treat cancer, can prevent the body from making riboflavin (as well as other essential vitamins).

Phenytoin - Phenytoin, a medication used to control epileptic seizures, may affect riboflavin levels in children.

Probenecid - This medication used for gout may decrease the absorption of riboflavin from the digestive tract and increase the excretion in the urine.

Selegiline - Similar to its effects on doxorubicin, riboflavin may deactivate selegiline, a medication used to treat Parkinson's disease, in the presence of daylight.

Sulfa-containing Medications - Riboflavin may reduce the effectiveness of sulfa-containing medications, such as certain antibiotics (for example, trimethoprim-sulfamethoxazole) used to treat bacterial infections.

In addition, as stated earlier, long-term use of antibiotics can deplete vitamin B levels in the body, particularly B2, B9, B12, and vitamin H (biotin), which is considered part of the B complex.  

Thiazide Diuretics - Diuretics that belong to a class known as thiazides, such as hydrochlorothiazide, may increase the loss of riboflavin in the urine.  


Possible Interactions with: Vitamin B3 (niacin)

Also listed as: Inositol Hexaniacinate; Niacin; Niacinamide; Nicotinamide; Nicotinic Acid; Vitamin B3 (Niacin)

If you are currently being treated with any of the following medications, you should not use niacin without first talking to your healthcare provider.

Antibiotics, Tetracycline - Niacin should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Niacin either alone or in combination with other B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

Aspirin - Taking aspirin before taking niacin may reduce flushing associated with this vitamin. This should only be done under the advice of a healthcare practitioner.

Blood Pressure Medications, Alpha-blockers - When niacin is taken with certain blood pressure medications known as alpha-blockers (such as prazosin, doxazosin, and guanabenz), the likelihood of side effects from these medications is increased.

Cholesterol-lowering Medications - Niacin binds bile-acid sequestrants (cholesterol-lowering medications such as colestipol, colesevelam, and cholestyramine) and may decrease their effectiveness. For this reason, niacin and these medications should be taken at different times of the day.

As described earlier, recent scientific evidence suggests that taking niacin with simvastatin (a drug that belongs to a class of cholesterol-lowering medications known as HMG-CoA reductase inhibitors or statins including atorvastatin and lovastatin as well), appears to slow down the progression of heart disease. However, the combination may also increases the likelihood for serious side effects, such as muscle inflammation or liver damage.

Diabetes Medications - People taking insulin, metformin, glyburide, glipizide, or other medications used to treat high blood sugar levels should monitor their blood sugar levels closely when taking niacin supplements.

Isoniazid (INH) - INH, a medication used to treat tuberculosis, may deplete levels of niacin and cause a deficiency.

Nicotine Patches - The use of nicotine patches with niacin may worsen or increase the risk of flushing reactions associated with this vitamin when used medicinally.


Possible Interactions with: Vitamin B6 (Pyridoxine HCL)

Also listed as: Pyridoxine; Vitamin B6 (Pyridoxine)

If you are currently being treated with any of the following medications, you should not use vitamin B6 supplements without first talking to your healthcare provider.

Antibiotics, Tetracycline - Vitamin B6 should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Vitamin B6 either alone or in combination with other B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

Antidepressant Medications, Tricyclic - Taking vitamin B6 supplements may improve the effectiveness of certain tricyclic antidepressants such as nortriptyline, especially in elderly individuals. Other tricyclic antidepressants include desipramine and imipramine.

On the other hand, another class of antidepressants called monoamine oxidase inhibitors (MAOIs) may reduce blood levels of vitamin B6. Examples of MAOIs include phenelzine and tranylcypromine.

Antipsychotic Medications - Preliminary evidence suggest that pyridoxine may prove useful in treating tardive dyskinesia, a common but frustrating side effect from medications used to treat schizophrenia. Tardive dyskinesia is marked by involuntary movements of the mouth and tongue. More research is needed to know if vitamin B6 can help prevent or treat this side effect.

Tuberculosis Medications - Anti-tuberculosis medications such as isoniazid (INH) and cycloserine (used for resistant forms of tuberculosis) reduce the levels of vitamin B6 in the blood.

Birth control medications Birth control medications may reduce blood levels of vitamin B6.

Chemotherapy - Vitamin B6 may reduce certain side effects of 5-fluorouracil and doxorubicin, two agents used to treat cancer without reducing the effectiveness of the chemotherapy.

Erythropoietin - Erythropoietin therapy used for severe anemia may decrease vitamin B6 levels in red blood cells. Therefore, vitamin B6 supplementation may be necessary during erythropoietin therapy.

Hydralazine - Vitamin B6 decreases the effectiveness of hydralazine, a medication used to treat high blood pressure.

Levodopa - Vitamin B6 reduces the effectiveness of levodopa, a medication used to treat Parkinson's disease.

Methotrexate - People with rheumatoid arthritis taking this medication often have low levels of vitamin B6.

Penicillamine - Penicillamine, a medication used in the treatment of rheumatoid arthritis and Wilson's disease (excessive amounts of copper in the body that can lead to liver damage) may decrease levels of vitamin B6 in the body.

Phenytoin - Vitamin B6 reduces the effectiveness of phenytoin, a medication used to treat seizures.

Theophylline - Long-term treatment with theophylline for asthma may reduce blood levels of vitamin B6.


Possible Interactions with: Folic Acid

Also listed as: Folacin; Folate; Folic Acid; Vitamin B9 (Folic Acid)

If you are currently being treated with any of the following medications, you should not use folic acid supplements without first talking to your healthcare provider.

Antibiotics, Tetracycline - Folic acid should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Folic acid either alone or in combination with other B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

In addition, long-term use of antibiotics can deplete vitamin B levels in the body, particularly B2, B9, B12, and vitamin H (biotin), which is considered part of the B complex.

Aspirin, Ibuprofen, and Acetaminophen - When taken for long periods of time, these medications, as well as other anti-inflammatories can increase the body's need for folic acid.

Birth Control Medications, Anticonvulsants, and Cholesterol-lowering Medications - Birth control medications, anticonvulsants for seizures (namely, phenytoin and carbamazapine), and cholesterol-lowering medications (namely, bile acid sequestrants including cholestyramine, colestipol, and colesevelam) may reduce the levels of folic acid in the blood as well as the body's ability to use this vitamin. Extra folate when taking any of these medications may be recommended by your healthcare provider. When taking bile acid sequestrants for cholesterol, folate should be taken at a different time of day.

Sulfasalazine - Sulfasalazine, a medication used for ulcerative colitis and Crohn's disease, may reduce the absorption of folic acid, leading to lower levels of folic acid in the blood.

Methotrexate - Methotrexate, a medication used to treat cancer and rheumatoid arthritis, increases the body's need for folic acid. Folic acid reduces the side effects of methotrexate without decreasing its effectiveness.

Other - Antacids, cimetidine, and ranitidine (used for ulcers, heartburn, and related symptoms) as well as metformin (used for diabetes) may inhibit the absorption of folic acid. It is best, therefore, to take folic acid at a different time from any of these medications.

Barbiturates, such as pentobarbital and phenobarbital, used for seizures, may impair folic acid metabolism.


Possible Interactions with: Vitamin B12 (Cyanocobalamin)

Also listed as: Cobalamin; Cyanocobalamin; Vitamin B12 (Cobalamin)

If you are currently being treated with any of the following medications, you should not use vitamin B12 supplements without first talking to your healthcare provider.

Antibiotics, Tetracycline - Vitamin B12 should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Vitamin B12 either alone or in combination with other B vitamins should be taken at different times of the day from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

In addition, long-term use of antibiotics can deplete vitamin B levels in the body, particularly B2, B9, B12, and vitamin H (biotin), which is considered part of the B complex.

Anti-ulcer Medications - The body's ability to absorb vitamin B12 is decreased when taking stomach acid-reducing medications such as omeprazole, lansoprazole, ranitidine, cimetidine, or antacids that are often used to treat gastroesophageal reflux, ulcers or related symptoms. This interference is most likely to occur as a result of prolonged use (more than one year) of these medications.

Chemotherapy Medications - Blood levels of vitamin B12 may be reduced when taking chemotherapy medications (particularly methotrexate) for cancer.

Metformin for diabetes - Blood levels of vitamin B12 may also be reduced when taking metformin for diabetes.

Phenobarbital and Phenytoin - Long-term treatment with either phenobarbital and phenytoin for seizure disorders may interfere with the body's ability to use vitamin B12.


Possible Interactions with: Vitamin B5 (d-Calcium Pantothenate)

Also listed as: Pantothenic Acid; Vitamin B5 (Pantothenic Acid)

If you are currently being treated with any of the following medications, you should not use vitamin B5 supplements without first talking to your healthcare provider.

Antibiotics, Tetracycline - Vitamin B5 should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)


Possible Interactions with:  Iodine (Kelp)

Also listed as: Iodine

There are no reports in the scientific literature to suggest that iodine interacts with any conventional medications. However, iodine should be used with caution by people taking thyroid medications.

 


Possible Interactions with: Magnesium (Oxide)

Also listed as: Magnesium

If you are currently being treated with any of the following medications, you should not use magnesium without first talking to your healthcare provider.

Antibiotics - The absorption of quinolone antibiotics (such as ciprofloxacin and moxofloxacin), tetracycline antibiotics (including tetracycline, doxycycline, and minocycline), and nitrofurantoin is diminished when taken with magnesium supplements. Therefore, magnesium should be taken two to four hours before or after taking these medications to avoid interference with absorption.

Blood Pressure Medications, Calcium Channel Blockers - Magnesium may increase the likelihood of negative side effects (such as dizziness, nausea, and fluid retention) from calcium channel blockers (particularly nifedipine) in pregnant women. Other calcium channel blockers include amlodipine, diltiazem, felodipine, and verapamil.

Diabetic Medications - Magnesium hydroxide, commonly found in antacids, may increase the absorption of glipizide and glyburide, medications used to control blood sugar levels. Ultimately, this may prove to allow for reduction in the dosage of those medications.

Digoxin - It is important that normal levels of magnesium be maintained while taking digoxin because low blood levels of magnesium can increase adverse effects from this drug. In addition, digoxin can lead to increased loss of magnesium in the urine. A healthcare provider will follow magnesium levels closely to determine whether magnesium supplementation is necessary.

Diuretics - Two types of diuretics known as loop (such as furosemide) and thiazide (including hydrochlorothiazide) can deplete magnesium levels. For this reason, physicians who prescribe diuretics may consider recommending magnesium supplements as well.

Hormone Replacement Therapy for menopause - Magnesium levels tend to decrease during menopause. Studies suggest, however, that hormone replacement therapy may help prevent the loss of this mineral. Postmenopausal women or those taking hormone replacement therapy should talk with a healthcare provider about the risks and benefits of magnesium supplementation.

Levothyroxine - There have been case reports of magnesium containing antacids reducing the effectiveness of levothyroxine, which is taken for an under active thyroid. This is important because many people take laxatives containing magnesium without letting their doctor know.

Penicillamine - Penicillamine, a medication used for the treatment of Wilson's disease (a condition characterized by high levels of copper in the body) and rheumatoid arthritis, can inactivate magnesium, particularly when high doses of the drug are used over a long period of time. Even with this relative inactivation, however, supplementation with magnesium and other nutrients by those taking penicillamine may reduce side effects associated with this medication. A healthcare practitioner can determine whether magnesium supplements are safe and appropriate if you are taking penicillamine.

Tiludronate and Alendronate - Magnesium may interfere with absorption of tiludronate, a medication similar to alendronate that is used for the treatment of osteoporosis. This interaction has not been reported with alendronate specifically. Magnesium supplements or magnesium-containing antacids should be taken at least two hours before or two hours after taking these medications to minimize potential interference with absorption.

Others - Aminoglycoside antibiotics (such as gentamicin and tobramycin), thiazide diuretics (such as hydrochlorothiazide), loop diuretics (such as furosemide and bumetanide), amphotericin B, corticosteroids, antacids, and insulin may lower magnesium levels. Please refer to the depletions monographs on some of these medications for more information.


Possible Interactions with: Zinc (Oxide)

Also listed as: Zinc

If you are currently being treated with any of the following medications, you should not use zinc without first talking to your healthcare provider.

Blood Pressure Medications, ACE Inhibitors - A class of medications called ACE Inhibitors, such as captopril and enalpril, used for high blood pressure may deplete zinc stores.

Antibiotics - Zinc may decrease the absorption of oral quinolones, a class of antibiotics that includes ciprofloxacin, norfloxacin, ofloxacin, and levofloxacin, as well as tetracycline antibiotics (including tetracycline, doxycycline, and minocycline).

Hormone Replacement Therapy (HRT) - HRT, consisting of estrogen and progesterone derivatives may reduce loss of zinc in the urine, particularly in women with osteoporosis.

Hydralazine - There has been at least one report of an interaction between zinc and hydralazine, a medication used to treat high blood pressure, which resulted in a lupus-erythematosus-like syndrome (characterized by a facial butterfly rash, fever, leg and mouth ulcers, and abdominal distress).

Immunosuppressant Medications - Since zinc supports immune function, it should not be taken with corticosteroids, cyclosporine, or other medications intended to suppress the immune system.

Nonsteroidal Anti-inflammatory Drugs (NSAIDs) - Zinc interacts with NSAIDs and could reduce the absorption and effectiveness of these medications. Examples of NSAIDs, which help to reduce pain and inflammation, include ibuprofen, naprosyn, piroxicam, and indomethacin.

Penicillamine - This medication, used to treat Wilson's disease (excessive amounts of copper that accumulate in the brain, liver, kidney, and eyes) and rheumatoid arthritis, decreases zinc levels.


Possible Interactions with: Selenium (Sodium Selenite)

Also listed as: Selenium

If you are currently being treated with any of the following medications, you should not use selenium supplements without first talking to your healthcare provider.

Cisplatin, Doxorubicin, and Bleomycin - Selenium may reduce toxic side effects associated with cisplatin and doxorubicin, two forms of chemotherapy used to treat cancer. On the other hand, a test tube study suggested that selenium may inhibit the anti-cancer effects of bleomycin.

Cholesterol-lowering Medications  Researchers recently discovered an unexpected adverse interaction between antioxidant supplements and a popular combination of cholesterol-lowering medications known as simvastatin and niacin -- this interaction may have important implications for patients with heart disease. Together, simvastatin and niacin have been shown to lower LDL ("bad") cholesterol and raise HDL ("good") cholesterol in people with heart disease. When taken with antioxidants (including selenium), however, these medications may not be as effective in raising HDL cholesterol.


Possible Interactions with: Copper (Gluconate)

Also listed as: Copper

If you are currently being treated with any of the following medications, you should not use copper supplements without first talking to your healthcare provider.

Birth Control Medications and Estrogen following menopause - Birth control medications and estrogen replacement for post-menopausal women can increase blood levels of copper. Therefore, copper supplements are not appropriate and may be cause for concern in individuals taking either of these medications.

Nonsteroidal Anti-inflammatory Drugs (NSAIDs) - Copper binds to NSAIDs (such as ibuprofen and naproxen) and appears to enhance their anti-inflammatory activity.

Penicillamine - Penicillamine (a medication used to treat Wilson's disease and rheumatoid arthritis) reduces copper levels that may be the intended use, as in the case of Wilson's disease.

Allopurinol - Test tube studies suggest that allopurinol, a medication used to treat gout, may reduce copper levels.

Cimetidine - Animal studies show that cimetidine, a medication used to treat ulcers and gastric esophageal reflux disease (when acid from the stomach enters the esophagus and causes heartburn and indigestion), may elevate copper levels in the body leading to damage of the liver and other organs.


Possible Interactions with: Manganese (Citrate)

Also listed as: Manganese

If you are currently being treated with any of the following medications, you should not use manganese supplements without first talking to your healthcare provider.

Haloperidol and other Antipsychotics - There has been at least one report of an interaction between haloperidol and manganese that resulted in hallucinations and behavioral changes in a person with liver disease. In addition, some experts believe that medications for schizophrenia and other forms of psychosis may worsen side effects from manganese supplements. Therefore, individuals taking haloperidol or other antipsychotic medications (particularly a class called phenothiazines which includes chlorpromazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, and trifluoperazine) should use manganese only under the careful supervision of a qualified health professional.

Reserpine - Reserpine, a medication used to treat high blood pressure, may decrease manganese levels in the body.


Possible Interactions with:Molybdenum (as Sodium Molybdate)

We are unaware of any interactions with this supplement.


Possible Interactions with: Acetyl L-Tyrosine

Also listed as: L-Tyrosine; Tyrosine

If you are currently being treated with any of the following medications, you should not use tyrosine supplements without first talking to your healthcare provider.

Antidepressant Medications, Monoamine Oxidase Inhibitors (MAOIs) - Tyrosine may cause a severe increase in blood pressure in people taking MAOIs (such as phenelzine, tranylcypromine, pargyline, and selegiline). This severe increase in blood pressure (also called "hypertensive crisis") can lead to a heart attack or stroke. For this reason, individuals taking MAOIs should foods and supplements containing tyrosine.

Appetite suppressant Medications

In a rat study, L-tyrosine increased the appetite-suppressant effects of phenylpropanolamine, ephedrine, and amphetamine. More research is needed to determine whether L-tyrosine produces similar results in humans.

Morphine - Although the application for humans is unclear, animal studies suggest that tyrosine increases the pain-relieving effects of morphine.

Levodopa - Tyrosine should not be taken at the same time as levodopa, a medication used to treat Parkinson's disease because levodopa may interfere with the absorption of tyrosine.  


Possible Interactions with: L-Phenylalanine

Also listed as: Phenylalanine

If you are currently being treated with any of the following medications, you should not use phenylalanine without first talking to your healthcare provider.

Antidepressant Medications, Monoamine Oxidase Inhibitors (MAOIs) - Phenylalanine may cause a severe increase in blood pressure in people taking MAOIs (such as phenelzine, tranylcypromine, pargyline, and selegiline). This severe increase in blood pressure (also called "hypertensive crisis") can lead to a heart attack or stroke. For this reason, individuals taking MAOIs should avoid foods and supplements containing phenylalanine.

Baclofen - The absorption of baclofen, a medication used to relieve muscle spasms, may be reduced by phenylalanine. Therefore, it is best to avoid taking this medication with a meal, especially one that is high in protein content, or with phenylalanine supplements.

Levodopa - A few case reports suggest that phenylalanine may reduce the effectiveness of levodopa, a medication used to treat Parkinson's disease. Some researchers speculate that phenylalanine may interfere with the absorption of this medication. Therefore, phenylalanine should not be taken at the same time as levodopa.