Monoplex Supplement Facts

Daily Dosage: As a dietary supplement, take two capsules in the morning and one capsule in the afternoon with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.

Monoplex Research:

Zinc- One of the most important minerals for immune function, zinc has been widely studied for prevention and treatment of infections. Low levels of zinc have been documented in patients with recurrent aphthous stomatitis, also known as canker sores (1).

In a zinc deficient patient who had not responded to any conventional medication and suffered from canker sores every month, after three months of oral zinc therapy the sores resolved and did not reappear for 1 year (2). A placebo-controlled study of oral zinc supplementation for one month demonstrated a significant reduction in sores in 40 patients with recurrent outbreaks (1). Another clinical study showed 50-100% reduction in the frequency of episodes in patients with low levels of zinc (3).

Vitamin B-12- Physicians recommend that deficiency of vitamin B12 should also be considered in all patients with recurrent canker sores (4).

When compared to healthy controls, patients with recurrent canker sores have significantly lower levels of vitamin B12, suggesting this important vitamin may play a role in the etiology of this condition (5). Recurrent canker sores have been shown to respond positively to treatment with vitamin B12 (6).

Folic Acid (folate)- Similar to vitamin B12, folate levels have also been found to be low in patients with recurrent oral ulceration when compared to healthy controls (7).

In a study of 330 patients, numerous nutritional deficiencies, including folate, were documented (8). Corrected nutritional deficiencies showed favorable responses to supplementation, with complete remission in many of the patients.

Iron - Deficiency of iron and other nutritional deficiencies were observed in a study of 330 patients (8). Correction of the nutritional deficiencies showed favorable responses to supplementation, with complete remission in many of the patients. When taken at optimal levels, a majority of people with canker sores have more rapid healing (9).

L-Lysine- Classically known as an anti-herpes nutrient, patients suffering from canker sores may also benefit from treatment with L-lysine. Research shows that L-lysine may be clinically effective in treating recurrent aphthous ulcers (10).

Glutamine- The preferred fuel for cells of the GI tract, glutamine is an amino acid that also exerts a protective effect on the gastrointestinal lining and plays a role in immune defenses.

Glutamine is effective in treating chemotherapy-induced stomatitis (inflammation of the mucous membrane of the mouth), and relieves associated pain (11). Glutamine has also demonstrated efficacy in healing ulceration of the mouth and increases the resistance of the colonic tissue to inflammatory injury (12,13).

Vitamin C- Patients with recurrent canker sores demonstrate significantly lower levels of the antioxidants vitamin C and vitamin A in both serum and saliva (14). Studies also show that people with canker sores have lower dietary intake of foods containing vitamin C (15). Vitamin C can increase white blood cell counts needed to heal ulcerations (16).

Deglycyrrhizinated licorice (DGL)- Another natural substance commonly used to treat sores from herpes, DGL may also benefit patients with canker sores. This form of licorice blocks the metabolism of certain prostaglandins which can improve healing of mucosal tissue, important in repairing ulceration of the GI tract (17).

A clinical study showed that 75% of patients treated with a DGL mouthwash experienced 50-75% improvement of canker sores within one day followed by complete healing of the ulcers by third day (18).

References:

1. Brownlie IV T et al. Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women. American Journal of Clinical Nutrition 2004;79(3):437-443.

2. Cook JD. Diagnosis and management of iron-deficiency anaemia. Best Pract Res Clin Haematol 2005 Jun;18(2):319-32.

3. Eden AN. Iron deficiency and impaired cognition in toddlers: an underestimated and undertreated problem. Paediatr Drugs 2005;7(6):347-52.

4. Sachdev H, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr 2005 Apr;8(2):117-32.

5. Krafft A et al. Effect of postpartum iron supplementation on red cell and iron parameters in non-anaemic iron-deficient women: a randomised placebo-controlled study. BJOG 2005 Apr;112(4):445-50.

6. Bolaman Z et al. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clin Ther 2003 Dec;25(12):3124-34.

7. Taksaki Y et al. [Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia] Rinsho Ketsueki 2002 Mar;43(3):165-9.

8. Kornberg A et al. Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives. Isr J Med Sci 1989 Mar;25(3):142-5.

9. Arinzon Z et al. Folate status and folate related anemia: a comparative cross-sectional study of long-term care and post-acute care psychogeriatric patients. Arch Gerontol Geriatric 2004 Sep-Oct;39(2):133-42.

10. Ma AG et al. Comparison of serum levels of iron, zinc and copper in anaemic and non-anaemic pregnant women in China. Asia Pac J Clin Nutr 2004;13(4):348-52.

11. Willis MS et al. Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination. Am J Clin Pathol 2005 Jan;123(1):125-31.

12. Van Lettow M et al. Low plasma selenium concentrations, high plasma human immunodeficiency virus load and high interleukin-6 concentrations are risk factors associated with anemia in adults presenting with pulmonary tuberculosis in Zomba district, Malawi. Eur J Clin Nutr 2005 Apr;59(4):526-32.

13. Gurgoze Mk et al. Plasma selenium status in children with iron deficiency anemia. J Trace Elem Med Biol 2004;18(2):193-6.

14. Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. Public Health Nutr 2000 Jun;3(2):125-50.

15. Sharma DC, Mathur R. Correction of anemia and iron deficiency in vegetarians by administration of ascorbic acid. Indian J Physiol Pharmacol 1995 Oct;39(4):403-6.