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Exoprin Supplement Facts

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Learn more about the ingredients in Exoprin.
Exoprin Supplement Facts

Serving Size: 4 Capsules
Servings Per Container: 30

Per Serving
Daily Value

Vitamin D (as Cholecalciferol) 400 IU 100%

Vitamin K (Phytonadione) 1000 mcg 1234%

MCHA (Bone Meal)
1724 mg
500 mg
155 mg

Magnesium (as Magnesium Oxide) 250 mg 62%

Zinc (as Zinc Oxide) 2 mg 13%

Copper (as Copper Gluconate) 3 mg 150%

Manganese (as Manganese Citrate) 1 mg 50%

Soy Extract
50 mg
20 mg

Ipriflavone 150 mg *

Boron (as Boron Citrate) 2 mg *

Other Ingredients: Vegetarian Capsule (Hypromellose), Rice Powder, Magnesium Stearate.
*Daily Value Not Established


Daily Dosage: As a dietary supplement, take two capsules in the morning and two capsules in the evening with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.


Exoprin Research:

Vitamin D- This essential nutrient is required for the absorption of calcium and musculoskeletal stability. A double-blind controlled trial in women over the age of 45 (peri- and pre-menopausal) who were given vitamin D and calcium showed a positive effect on bone mineral density (1). Researchers recommend that supplementation start early to prevent postmenopausal bone loss. A review of randomized controlled trials showed that supplementation with vitamin D can reduce the incidence of hip fracture, a devastating complication of osteoporosis (2).

Calcium- Necessary for bone mineral density (BMD), calcium is one of the most important nutrients in preventing osteoporosis. A Cochrane Review and a meta-analysis of randomized trials in postmenopausal women both indicated that even on its own, calcium can reduce the rate of bone loss and may prevent vertebral fractures (3,4). However, the combination of vitamin D and calcium is a more effective approach to maintaining BMD, even in subjects with good dietary intakes, as vitamin D helps with intestinal absorption of calcium (5). When given in combination with calcitriol, calcium can also reduce the rate of bone loss in renal transplant patients, who are at increased risk of osteoporosis (6). Vitamin D and calcium can decrease bone loss in corticosteroid-induced osteoporosis, as well.

Vitamin K- Vitamin K facilitates the formation of a bone-building protein and dramatically reduces fracture risk. In postmenopausal women, lower vitamin K status is correlated with reduced BMD. In a double-blind placebo-controlled trial involving women between the ages of 50-60, a supplement containing additional vitamin K1 demonstrated a dramatic effect on postmenopausal bone loss (7).

Soy Extract Isoflavones (including genistein, daidzein, and glycitein )- Soy extracts have been shown to improve estrogen-related bone loss. A double-blind controlled study of 203 postmenopausal women (who were also taking vitamin D and calcium) showed that soy isoflavones had a significant, independent effect on the maintenance of hip bone mineral content in postmenopausal women with low initial bone mass (8).

Ipriflavone (a semisynthetic isoflavone manufactured in the laboratory from daidzein, a compound derived from soy)- Some studies have shown that like vitamin D ipriflavone can enhance calcium absorption (9). It appears that ipriflavone also directly affects bone cells, resulting in increased bone construction (10). A clinical trial of ipriflavone in postmenopausal women showed that it could prevent the increase in bone turnover and the decrease in bone density that follow ovarian failure (11). In women with documented osteoporosis, ipriflavone treatment can significantly increase bone mineral density and can rapidly decrease pain and intake of analgesics, along with laboratory measures associated with bone loss (12).

MINERALS: Several minerals are important in bone growth and structure building.

Magnesium- Animal research has shown that magnesium supplementation can suppress bone resorption (13). Higher intake of magnesium is associated with increased BMD in both older men and women (14).

Zinc- Subclinical zinc deficiency can contribute to bone loss in the elderly (15). Dietary and plasma levels of zinc are lower in men with osteoporosis, and BMD was correlated with zinc (16).

Manganese- Lower levels of manganese are more common in osteoporotic patients than subjects with normal BMD (17). Bone loss in older postmenopausal women on calcium supplements can be further halted with the addition of trace minerals including manganese and zinc (18).

Boron- The combination of boron and magnesium has a profound effect on calcium metabolism and boron deprivation can lead to bone loss (19). Supplementation with boron in age-related bone loss is indicated when vitamin D, magnesium, or potassium is lacking (20).


Di Daniele N et al. Effect of supplementation of calcium and vitamin D on bone mineral density and bone mineral content in peri- and post-menopause women; a double-blind, randomized, controlled trial. Pharmacol Res 2004 Dec;50(6):637-41.

Bischoff-Ferrari HA. Fracture Prevention With Vitamin D Supplementation: A Meta-analysis of Randomized Controlled Trials. Journal of the American Medical Association 2005;293(18):2257-2264.

Shea B et al. Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Rev 2004;(1):CD004526.

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