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Menstium Supplement Facts

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Learn about the ingredients in Menstium.
  Menstium Supplement Facts

  Serving Size: 2 Capsules
  Servings Per Container: 30

Per Serving
Daily Value

  Vitamin E (d-Alpha Tocopheryl Succinate) 200 IU 667%

  Vitamin B6 (Pyridoxine HCL) 75 mg 3750%

  Magnesium (Magnesium Oxide) 350 mg 88%

  Chasteberry Extract (Vitex agnus-castus) (fruit) 75 mg *

  Dong Quai Extract(Angelica sinensis) (root) 25 mg *

   Licorice Extract (Glycyrrhiza glabra) (root) 500 mg *

  L-Theanine 100 mg *

*Daily Value Not Established



Other Ingredients: Vegetarian Capsule (Hypromellose), Magnesium Stearate, Rice Powder.

Daily Dosage: As a dietary supplement, take one capsule in the morning and one capsule in the afternoon with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.




Menstium Research:

Magnesium- Research shows that levels of red blood cells and mononuclear cell magnesium are significantly lower in women with premenstrual syndrome (PMS) when compared to healthy controls (1). In a controlled study of women with PMS who took magnesium daily for two months, symptoms of weight gain, swelling of extremities, breast tenderness and abdominal bloating were significantly reduced in the second month when compared to placebo (2). Magnesium supplementation is effective in reducing negative moods in the second month of treatment (3). Women with menstrual pain (primary dysmenorrhea) can also benefit from magnesium therapy (4).

Vitamin B6- Necessary for magnesium entrance into the cells, vitamin B6 may play a role in its therapeutic effects. Vitamin B6 also regulates the hepatic metabolism of estrogen, helping to remove it from the body. A study of 630 women with PMS was conducted where women were supplemented with varying levels of pyridoxine (a form of B6). The results showed that 40-60% of patients (depending on strength of dose) reported no significant residual complaints, while 65-88% noted a positive effect of the treatment (5).

Chasteberry (Vitex agnus-castus)- A medicinal plant used to effectively treat a variety of gynecologic disorders, vitex is quite useful for patients with PMS. Recent research shows that vitex acts on opiate receptors in the brain, supporting its beneficial effects on PMS (6). A clinical study of a vitex extract administered to women with PMS demonstrated a 43% reduction in overall symptoms and a slightly shortened duration of symptoms (7). A larger trial of vitex observed that after a 3 month treatment period 93% of women reported a decrease in the number of symptoms or even cessation of PMS complaints, and noted good or very good tolerance (8).

Angelica Sinensis (Dong Quai)- Dong Quai is traditionally used in Chinese Medicine to treat menstrual cramps, irregularity, delayed or irregular flow, weakness during the menstrual period, and breast tenderness. Research shows that when used in multiple herb formulations, dong quai demonstrates some efficacy in treating PMS (9).

Licorice (Glycyrrhiza glabra)- Another medicinal plant with a long history of use in treating female disorders, licorice appears to lower estrogen levels while raising progesterone levels, which can be of benefit in PMS patients (10). Licorice that has not had the component glycyrrhizin removed should be avoided by patients with hypertension, angina, renal failure and anyone taking digitalis preparations.

Vitamin E- A randomized, double-blind controlled trial of women with PMS who were given d-alpha-tocopherol (a form of vitamin E) or placebo daily for three months showed significant improvements in both emotional and physical symptoms associated with the onset of menses (11). Another double-blind study involving alpha-tocopherol demonstrated similar results with reductions in three out of four PMS symptom categories and suggested the effects may be mediated through changes in androgen levels like DHEA-S (12).


L-Theanine- This natural phytochemical is found in high levels in green tea and has traditionally been used as a relaxing agent. Recent research supports its historical use, showing that L-theanine induces relaxing effects under resting conditions which can be helpful for certain symptoms of PMS (13).



1. Rosenstein DL et al. Magnesium measures across the menstrual cycle in premenstrual syndrome. Biol Psychiatry 1994 Apr 15;35(8):557-61.

2. Walker AF et al. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. J Womens Health 1998 Nov;7(9):1157-65.

3. Facchinetti F et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol 1991 Aug;78(2):177-81.

4. Benassi L et al. Effectiveness of magnesium pidolate in the prophylactic treatment of primary dysmenorrhea. Clin Exp Obstet Gynecol 1992;19(3):176-9.

5. Brush MG, Bennett T, Hansen K. Pyridoxine in the treatment of premenstrual syndrome: a retrospective survey in 630 patients. Br J Clin Pract 1988 Nov;42(11):448-52.

6. Webster DE et al. Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: Implication for its use in PMS. J Ethnopharmacol 2006 Jan 23; [Epub ahead of print]

7. Berger D et al. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet 2000 Nov;264(3):150-3.

8. Loch EG, Slle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med 2000 Apr;9(3):315-20.

9. Hardy ML. Herbs of special interest to women. J Am Pharm Assoc (Wash) 2000 Mar-Apr;40(2):234-42; quiz 327-9.

10. Kumagai A et al. Effect of glycyrrhizin on estrogen action. Endocrinol Japan 1967;14:34-38.

11. London RS et al. Efficacy of alpha-tocopherol in the treatment of the premenstrual syndrome. J Reprod Med 1987 Jun;32(6):400-4.

12. London RS et al. The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study. II. Endocrine correlates. J Am Coll Nutr 1984;3(4):351-6.

13. Lu K et al. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol 2004 Oct;19(7):457-65.