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Oxycollasyn uses multiple patented ingredients in its formulation. These are to improve the performance of classic anti-arthritis remedies. But how effective is this advanced formula? Read on to find out.

What is Oxycollasyn?

Oxycollasyn is an all-natural, oral joint aid formulation meant to treat arthritis and other joint disorders.

Oxycollasyn uses a unique formulation of known, effective, and clinically proven ingredients. Instead of simply mixing the most effective natural remedies for joint pain and inflammation, the manufacturers of Oxycollasyn combined these ingredients into 7 patented complexes.

Some might argue that Oxycollasyn simply uses fancy names for commonly available ingredients (for example, Biocell Collagen II is a mixture of collagen and hyaluronic acid), however, these ingredients are combined in certain ratios and delivered in certain ways to improve the bioavailability and synergistic effect of the ingredients.

The 7 Patented Ingredients


Reganasure is a patented glucosamine formulation. While the most popular source of glucosamine used in dietary supplements and arthritis remedies is shellfish, the glucosamine used in Oxycollasyn is taken from non-shell fish vegetarian sources.

Therefore, people with shellfish allergy can safely take Oxycollasyn.

Biocell Collagen II

Biocell is a concentrated formulation of collagen type II and hyaluronic acid.

Collagen is the most abundant protein in cartilages; therefore, Biocell helps regenerate the cartilage and protect it from oxidative damage. There are 28 types of collagen present in the body and collagen II accounts for 50% of these. Also, collagen II is the type of collagen found in cartilages.

Several studies have found that oral administration of collagen improves the symptoms of arthritis.

Hyaluronic acid is one of the 2 lubricants present in synovial fluid. Its major function is to enable the smooth sliding of bones over one another. Hyaluronic acid also protects the chondrocytes of the cartilage and it is responsible for linking glycosaminoglycans together during the production of cartilage.

Opti MSM

Opti MSM is a patented version of methylsulfonylmethane or MSM.

MSM is a natural sulfur source needed in the body for linking together amino acids to make proteins. It is needed to supply the sulfide bonds in proteins such as collagen which are then used to make connective tissues.

The strength of the sulfide links supplied by MSM is directly responsible for the elasticity and flexibility of joint cartilage.


Celadrin is a lubricant formulation included to promote the fluidity of cell membranes and improve joint lubrication. Celadrin also helps reduce the swelling of inflamed joints.


Fruitex-B is an antioxidant system included in Oxycollasyn. Its role is to mop up harmful free radicals which can cause long-term damage to the tissues of the joint. Therefore, Fruitex-B also protects joints from autoimmune damage. Its overall effect is to relieve painful joint inflammation.


5-Loxin is a patented extract of boswellia. It is 10 times more potent than other boswellia extracts in the market.

Boswellia extract contains Boswellia acids which have anti-inflammatory and anti-oxidant properties.


SAMe or S-adenosyl methionine is produced from the energy molecule, ATP or adenosine triphosphate.

Studies have shown that SAMe is effective for reducing osteoarthritis pain. Its effect was found comparable to non-steroidal anti-inflammatory drugs (NSAIDs) although it produces far fewer side effects.

Other Ingredients of Oxycollasyn

Glucosamine Sulfate

Glucosamine sulfate is an amino sugar that is used to make the glycosaminoglycans that form the structure of cartilages. It is naturally found in bones and bone marrow.

Besides contributing to the rebuilding of the cartilage, glucosamine sulfate also improves the lubricating property of the synovial fluid and slows down the degeneration of the cartilage.

Chondroitin Sulfate

Chondroitin sulfate is a glycosaminoglycan formed from 2 monosaccharides: D-glucuronic acid and N-acetyl-D-galactosamine. These monosaccharides alternate to form the long-chain polysaccharide that makes up the basic structure of chondroitin.

Each of the monosaccharides in chondroitin carries one, two, or no sulfate groups. This gives the molecule an overall negative charge.

When chondroitin molecules are packed together to form the extracellular matrix of cartilages, the charge generates a repulsive force between the molecules. The repulsive force produces the resistance to compressive force as well as the elasticity and flexibility of the cartilages in joints.

Therefore, chondroitin sulfate slows down cartilage degeneration while promoting the regeneration of new cartilage.

Hyaluronic acid

Hyaluronic acid is also a glycosaminoglycan like a chondroitin sulfate. However, unlike chondroitin, it carries no sulfate groups.

Hyaluronic acid serves as a lubricant in synovial fluid. In this role, it allows the smooth articulation of bones and connective tissues in the joint.

Other roles of hyaluronic acid include protecting chondrocytes from oxidative damage and linking other glycosaminoglycans to proteins during the production of new cartilage.

Cetyl Myristoleate

Cetyl myristoleate or CMO is a waxy ester that was found to be the reason mice never get arthritis. It was discovered 25 years before it was ever sold. In a curious story, cetyl myristoleate is one of the new effective anti-arthritis remedies available.

Cetyl myristoleate lubricates the joints and it also blocks the production of leukotrienes and prostaglandins to produce its anti-inflammatory effects.

Some studies have established the efficacy of cetyl myristoleate in the treatment of arthritis. In this role, its efficacy was found comparable to that of NSAIDs as well as glucosamine and chondroitin.


Bromelain is a protein-digesting enzyme obtained from the stems of pineapples. It is effective for treating inflammation and it works by inhibiting pro-inflammatory chemokines.

Vitamin C

Vitamin C or ascorbic acid is an antioxidant that can protect the cartilage.

However, more importantly, vitamin C increases the conversion of proline to hydroxyproline which is then used in the production of collagen. Therefore, vitamin C contributes to the regeneration of the cartilage by promoting the production of collagen.


A ginger extract will reduce joint pain, inflammation, and also has an antioxidant property.

Ginger reduces inflammation by inhibiting the production of LTB4, leukotriene, and PGE2, a prostaglandin. It also blocks TNF-alpha (tissue necrosis factor-alpha), a proinflammatory factor.


Turmeric is also a rhizome like ginger and they are both related.

The active ingredient of turmeric is curcumin. Curcumin is a natural food colorant and a medicinal agent. It has antimicrobial, anti-tumor, anti-arthritic, anticoagulant anti-inflammatory, and antioxidant properties.

Curcumin inhibits prostaglandins and leukotrienes such as PGE2, LTB4, and LTC4. It increases the production of type II collagen, and it blocks enzymes that break down collagen.

To improve the absorption of curcumin, it is usually combined with piperine. Oxycollasyn uses this combination by including Bioperine (a patented compound containing high amounts of piperine).

Cat’s Claw

Cat’s claw refers to the 2 species of Uncaria plant: U. guianensis and U. tomentosa. The extract of Cat’s claw contains anti-arthritis remedies such as rutin, epicatechin, and proanthocyanidins.

Cat’s claw has been shown to improve arthritis symptoms in different clinical trials. Its anti-inflammatory effect is due to its ability to block TNF-alpha and PGE2.

Green-Lipped Mussel

Green-lipped mussel is a bivalve mollusk native to New Zealand.

Preliminary results show that this shellfish may be useful for treating arthritis symptoms. It inhibits the 5-lipooxygenase pathway and, therefore, blocks the formation of leukotrienes.

Hops 4:1

Hops are the female flowers of Humulus lupulus. It is an old remedy used in traditional medicine.

The different varieties and preparations of hops are characterized by their alpha acid: beta acid ratios. Therefore the 4:1 hop ratio in Oxycollasyn means that there are 4 times more alpha acids in hops than beta acids.

Examples of alpha acids are cohumulone and adhumulone; beta acids include lupulone, colupulone, and adlupulone. Alpha acids are the better of the two types of acids. They have been shown to possess antibiotic properties

Other active ingredients of Oxycollasyn are avocado, white willow, alfalfa, barley, buckwheat, devil’s claw, cayenne, flaxseed, wheatgrass, garlic, acai, soy isoflavones, copper, and Lactobacillus acidophilus.

Is Oxycollasyn Effective?

The recommended dose for Oxycollasyn is 3 tablets daily.

Oxycollasyn contains the right blend of active ingredients to help repair damaged cartilage and promote joint health. And it contains those ingredients in new, innovative, patented formulations.

Of special note is the inclusion of type II collagen. Collagen is not a popular ingredient in joint support formulas and of those medications which do include collagen, very few include the specific collagen used to make cartilage.

Such attention to detail and multi-focus formulation put Oxycollasyn at the top of any list of joint support medications.

But how does this unique formulation perform in real life?

Oxycollasyn has a high success rate with users (an average of 97% of users report positive results from using it). However, there are very few independent clinical trials that show that its patented ingredients do better than similar ingredients included in other competing medications.

Furthermore, Oxycollasyn contains a lot of ingredients; perhaps too much.

There are over 30 ingredients listed on the product’s page while only 10 are listed on its label. It is unclear if some of the listed ingredients are also included in the patented ingredients.

In a way, Oxycollasyn may suffer from trying too much. Some ingredients may conflict with others, and sometimes there seem to be no clear-cut goals for some combinations of its ingredients.

For example, while the manufacturer boasts that the included glucosamine sulfate is not derived from shellfish, Oxycollasyn also includes green-lipped mussel which is a shellfish. Therefore, while the product is marketed as safe for people with shellfish allergies, it really does contain some amount of shellfish.

Still, Oxycollasyn represents an advanced formulation for joint support. It is effective and given the number of patented ingredients it contains, it is also affordable.




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