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Learn More About Rebuild Plus for Osteo

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Rebuild Plus from Metabolic Maintenance contains all the right minerals and vitamins for improving bone health. Unlike most osteoporosis supplements, it is more than a simple combination of calcium and vitamin D. Rebuild Plus not only contains calcium but it does contain the best vitamin D vitamer for bone health. The inclusion of little-known but effective natural osteoporosis remedies such as boron, copper and vitamin C also improves the effectiveness of Rebuild Plus. But is it safe? Yes. Is it the perfect osteoporosis supplement? Read on to find out.

What is Rebuild Plus?

Rebuild Plus is an osteoporosis dietary supplement from Metabolic Maintenance. It differs from the regular Rebuild formula from the same manufacturer by the addition of more vitamin D3.

Each bottle of Rebuild Plus contains 180 capsules. The daily dose of this supplement is 6 capsules.

Ingredients of Rebuild Plus

Metabolic Maintenance based the formulation of Rebuild Plus on the 1993 paper published in the Journal of the American College of Nutrition by Saltman and Strausse.

In that paper, the authors highlighted the roles of trace minerals in the treatment of osteoporosis. They identified that calcium was not the only mineral important for optimal bone health. Other important minerals identified in the paper include zinc, copper, and manganese.

A 2005 study published in The American Journal of Clinical Nutrition provided an updated review of the roles of micronutrients in the treatment of osteoporosis.

This study added phosphorus, potassium, fluoride, boron, silicon and vitamin C to the list of nutrients that have been proven to improve bone mineral density and reduce the risk of osteoporotic bone fractures.

Most of these micronutrients are found in Rebuild Plus but how can help people with osteoporosis?

How the Active Ingredients of Rebuild Plus Work


Calcium is the most abundant mineral found in the bone. It directly contributes to bone mass and bone strength.

When calcium is stripped from the bones, it leaves them porous, shallow and weak. Because the amount of calcium stored in the bones, falls with age especially among postmenopausal women, it is important to raise calcium intake as we grow older.

Fortunately, calcium is found abundantly in foods especially milk and dark, leafy vegetables. Calcium supplements are also routinely prescribed to prevent and/or treat osteoporosis.

While calcium supplementation is good for bone health, high doses of calcium can be bad for the bones, kidneys and cardiovascular health.

Each capsule of Rebuild Plus contains 167 (17% of the recommended daily intake) mg of calcium. Therefore, the daily dosage (6 capsules) of the supplement provides a little more than the recommended daily intake of calcium.

Magnesium and Manganese

Magnesium and manganese are functionally related minerals even though the body stores a great deal more magnesium than manganese.

Both minerals are naturally found in the bone and share the same benefits for bone health.

Magnesium only makes up 1% of the mineral content of the bone (manganese makes up even less). However, magnesium is required to give strength to the basic crystalline bone units made from calcium and phosphorus.

Therefore, low magnesium levels cause the bone to become porous, hollow and brittle.

Besides its direct effect on the bone, magnesium also promotes the absorption of calcium into the blood and its onward distribution to the bones.

Magnesium ensures that calcium is driven from the blood to the bones by increasing its sensitivity to vitamin D and influencing hormones such as calcitonin and parathyroid hormone.

Lastly, magnesium is an alkalizing agent. Therefore, it replaces calcium as the primary alkalizing agent for neutralizing acidic food components and drugs that lower the pH of the blood. In this way, magnesium preserves the calcium in the bones.


Like magnesium, zinc is responsible for only a small proportion of the mineral content of the bone but it is a lot more important to bone strength.

Zinc also contributes to the proper formation of the microcrystalline unit of the bone.

Besides its structural role in the bone, zinc can also improve bone growth by promoting the release of insulin-like growth factor (IGF-1) from the liver. IGF-1 is involved in bone growth and also the development of muscular strength.

Studies have confirmed that zinc can improve bone mineral density by stimulating the release of this hormone.

In addition, zinc also regulates the activities of osteoblasts and osteoclasts. Osteoblasts are cells that promote the formation of new bones while osteoclasts are responsible for bone resorption.

By enhancing the activities of osteoblasts and inhibiting osteoclasts, zinc increases bone mineral density and reduces the risk of bone fractures.


Severe bone deficiency has been shown to have negative effects on the bone.

The most important contribution of copper to bone health involves the formation of collagen. Copper is an essential cofactor for enzymes such as lysyl oxidase. This enzyme is important for the cross-linking of collagen.

Collagen is a fibrous protein found in the bone and connective tissues such as tendons and cartilages.

Therefore, copper provides structural support for the bone in different ways. It improves bone health and muscular support for bones.


Boron is a non-essential mineral in humans. Therefore, only a few studies have been conducted to investigate its effects on human health.

In one of these studies, researchers placed a group of postmenopausal women on a boron supplement. The results of the study showed that boron lowered calcium excretion by 44% and reduced the risk of bone fractures.

Besides reducing calcium loss, the researchers also found that boron enhances the activities of estrogen and vitamin D.

These 2 effects are important for bone health because vitamin D helps the bone take up more calcium. Estrogen is also needed for optimal bone health. In fact, falling estrogen levels is one of the major causes of osteoporosis among postmenopausal women.

Therefore, boron may be needed in trace amounts but it is excellent for bone health.

Rebuild Plus contains 2 mg of boron in the forms of the boron salts, boron citrate and boron aspartate.

Vitamin C

Although vitamin C has no direct effect on the body, epidemiological studies have identified that low intake of the vitamin is associated with faster loss of bone minerals.

Other studies have also linked higher consumption of vitamin C with a lower risk of bone fractures.

Because vitamin C is a cofactor in the syntheses of collagen precursors such as hydroxyproline and hydroxylysine, it is can also provide structural support for bones and the muscles that surround them.

Vitamin D3

Vitamin D is important for the absorption of calcium and the regulation of the blood and bone levels of the mineral.

In addition, it is involved in the regulation of phosphate levels. Because the bulk of the bone is made up of calcium and phosphate, vitamin D is very effective for increasing bone mineral density and for reducing the risk of bone fractures.

Vitamin D is also important for reabsorbing the calcium and phosphates released when osteoclasts break down bones.

Therefore, the vitamin can help increase the efficiency of bone metabolism and reduce calcium loss.

Studies have shown that the most important form of vitamin D is vitamin D3. This is the form of vitamin D found in Rebuild Plus and it is provided in 2,000 IU per day (5 times the recommended daily intake of the vitamin).

Vitamin K1

The importance of vitamin K to bone health is a recent discovery. Studies indicate that this vitamin is even more important to calcium utilization in bones than vitamin D.

The addition of vitamin K to the combination of calcium and vitamin D produces significantly better results than simply combining vitamin D with calcium. Vitamin K moves calcium to the bones and promotes the uptake of calcium into the bone matrix.

To improve bone mineralization, vitamin K promotes the activities of osteoblasts. Specifically, it stimulates the release of osteocalcin, a protein necessary for binding calcium to bones.

Vitamin K promotes the carboxylation of osteocalcin. This step is needed to activate the protein and increase bone mineralization.

Studies show that low vitamin K levels is associated with high levels of uncarboxylated osteocalcin.

Furthermore, these studies show that vitamin K reduces urinary calcium loss and inhibits bone resorption.

High doses of vitamin K were found effective for increasing bone mineral density, lowering the risk of osteoporotic fractures and stroke (a complication of high calcium supplementation without the correspondingly high intake of magnesium, vitamin D and vitamin K).

The daily dose of Rebuild Plus provides 125% the recommended daily value of vitamin K. However, the formulation uses vitamin K1 which is the less effective of the 2 natural vitamers of vitamin K.

Is Rebuild Plus Effective?

It is hard to come across an online review of Rebuild Plus. This is likely an indication that it is not a popular product. However, it does not suggest that Rebuild Plus is ineffective or unsafe.

In fact, a frank review of its ingredients indicates that Rebuild Plus is most likely effective and safe.

The formulation of this supplement is based on solid evidence-based medicine. The active ingredients used in the product are all proven to increase bone mineral density and help people (especially postmenopausal women) with osteoporosis. 

The inclusion of little-known minerals like boron and the emphasis on vitamin D3 show that the manufacturer paid attention to small details in the formulation of this supplement.

However, there are a couple of oversights in the formulation of Rebuild Plus.

First, the daily dose of calcium from this supplement is rather too high. At 1000 mg, Rebuild Plus can provide all the calcium that an individual needs for a day. But calcium can also be easily obtained from foods. Therefore, it is very likely that users will end up with a lot more calcium than is healthy.

Studies have shown that even though osteoporosis patients need calcium, they do not need high doses of the mineral.

Above 1000 – 1200 mg (from both foods and dietary supplements), calcium becomes does more harm to the body than good for the bone.

In addition, there is no point taking more than 600 mg of calcium per dose since that is the upper limit of the amount of calcium that can be absorbed from the intestines at a given time.

However, this high dose of calcium in Rebuild Plus can be forgiven because the supplement also includes magnesium, vitamin D and vitamin K. These micronutrients help remove calcium from the blood and deposit it in the bones where it is needed.

Even then, there is still the danger of hypermineralization. While a lower calcium dose would have been more appropriate, users of Rebuild Plus should avoid major dietary sources of calcium.

The second flaw with Rebuild Plus formula involves the choice of vitamin K used in the supplement.

Rebuild Plus contains vitamin K1. While vitamin K1 can improve bone health, better results are produced by vitamin K2.

Studies show that vitamin K2 is superior to vitamin K1 in multiple ways especially in its regulation of the activities of osteoblasts and osteoclasts.

However, these 2 flaws do not make Rebuild Plus ineffective. It can definitely be better but the supplement should still produce good results.

Lastly, all of the ingredients of Rebuild Plus are naturally found in the body and they are supplied in tolerable doses. Therefore, this supplement is not only effective but also safe.





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