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How Revivogen Helps Hair Loss

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Revivogen is a 3-component, dermatologist-formulated hair loss product from Advanced Skin & Hair Inc. This topical formulation packs a number of natural hair loss remedies. The main mechanism of action of Revivogen is by blocking the conversion of testosterone to dihydrotestosterone. Read on to discover how the active ingredients of Revivogen do this and why inhibiting this conversion is important.

*Note: ProgressiveHealth.com does not carry Revivogen. The following review is simply for informational purposes:

What is Revivogen?

Revivogen is a topical hair loss formula that is made of natural ingredients proven to promote hair regrowth. It is a dermatologist-formulated product from Advanced Skin & Hair Inc.

There are 3 different topical solutions in each pack of Revivogen. These are named Revivogen’s Scalp Therapy, Bio-Cleansing Shampoo, and Thickening Conditioner. Revivogen is made into these 3 products so that it can easily be integrated into the user’s daily hair care routine.

Although the Scalp Therapy is the most important part of this 3-formulation product, it contains the same active ingredients as the Bio-Cleansing Shampoo.

How Revivogen Works

The Active Ingredients of Revivogen
  • Alpha-linolenic acid
  • Gamma linolenic acid
  • Linoleic acid
  • Oleic acid
  • Azelaic acid
  • Zinc
  • Vitamin B6
  • Beta-sitosterol
  • Saw Palmetto
  • Proanthocyanidins

To use Revivogen Scalp Therapy, first comb back your hair, then take 1 – 2 mL of the topical solution with the included dropper. Apply this to the affected area and repeat the application, parting the hair and dropping the solution along the length of your scalp.

If the solution drips, massage it into your scalp with your hands. Leave the scalp treatment on overnight or for some hours if applied in the morning. On the other hand, the Bio-Cleansing Shampoo should only be left on for a few minutes before washing off.

The Thickening Conditioner is added to help give the thinning and new hair volume.

Revivogen is generally well tolerated and free of side effects. However, a small percentage of users may experience scalp irritation characterized by redness and itching.

From the product’s website, the manufacturer promises that Revivogen will stop hair loss within the first month of use. Continuous use for another 3 months should produce significant hair regrowth and, thereafter, the users’ hair becomes fuller and denser.

Revivogen can be combined with other popular hair loss medications including topical solutions such as Rogaine. However, at least 3 hours should be allowed between the two products to reduce the chance of negative interactions.

Revivogen can also be used by people who have undergone a hair transplant.

Unlike hair loss products like Rogaine, the use of Revivogen can be reduced over time. After the first 12 -16 months of use, those who benefit from Revivogen can gently taper down the amount applied or reduce the frequency of application from daily to 3 -5 days per week.

If hair loss continues 6 months after starting on Revivogen, then it is unlikely that the hair loss product will work and, at that point, it should be discontinued.

How Revivogen Works

Revivogen is effective for androgenic alopecia. This is also known as male-pattern hair loss and it affects both men and women.

Androgenic alopecia is the most common form of hair loss. It is caused by androgens or male sex hormones. The major hormone that triggers hair loss is DHT or dihydrotestosterone.

DHT is a metabolite of testosterone, the chief male sex hormone. The conversion of testosterone to DHT is driven by the enzyme, 5-alpha reductase which is found in hair follicle cells. When the amount of DHT rises in the body, the hormone mostly accumulates inside hair follicles.

While the conversion of testosterone to DHT happens in everyone, some people are more genetically sensitive to DHT.

DHT causes hair loss by killing off hair follicle cells. However, before these cells are destroyed, DHT gradually reduces their efficiency by disrupting essential cellular processes. This causes the shortening of the growth phase and the lengthening of the resting phase of the hair growth cycle.

At first, DHT causes the thinning of the hair on the scalp. Later, the rate of hair loss overtakes the rate at which new hair replaces the lost ones.

The hair loss caused by DHT can be slowed down, stopped and even reversed if treated early.

However, if hair loss treatment is delayed, most of the hair follicles on the scalps would have been destroyed and the resulting hair loss becomes irreversible.

Revivogen is meant to be used before the hair follicle cells are killed. Here is how the active ingredients in Revivogen help:

  • blocks the entry of testosterone into hair follicle cells
  • blocks the conversion of testosterone to DHT within hair follicle cells
  • blocks androgen receptors and prevent the androgen hormones from binding to them
  • stimulates hair follicles by activating and lengthening their growth phase

The Active Ingredients of Revivogen

The Free Fatty Acids

The free fatty acids found in Revivogen have been proven to block the enzyme needed to convert testosterone to DHT.

These plant-derived free fatty acids include alpha-linolenic acid, gamma-linolenic acid, linoleic acid and oleic acid.

While alpha-linolenic acid is a polyunsaturated omega-3 fatty acid, gamma-linolenic is a polyunsaturated omega-6 fatty acid.

Alpha-linolenic acid is well studied and it showed promise in different clinical trials for the treatment of anxiety, stress, and depression. It has also been shown to reduce the risk of cardiovascular disease.

Gamma linolenic acid, on the other hand, is known for its anti-inflammatory properties. It is commonly used to treat eczema, arthritis and other autoimmune disorders. Linoleic acid is also an omega-6 fatty acid and it is converted to gamma-linolenic acid in the body.

Oleic acid is a monounsaturated omega-9 fatty acid that is commonly used as an emulsifying agent in the pharmaceutical industry. This fatty acid can lower blood pressure and protect the brain and the adrenal glands.

All of these unsaturated fatty acids have some degree of activity against 5-alpha reductase.

In one study published in Biochemistry Journal in 1992, the researchers measured the activities of a group of unsaturated fatty acids against this enzyme. The result of the study showed that gamma linolenic acid is the most potent of the 4 free fatty acids included in Revivogen.

All of the fatty acids block the conversion of testosterone to DHT but to different degrees. Following gamma-linolenic acid, the potencies of the others in decreasing order are alpha-linolenic acid, linoleic acid, and oleic acid.

A 2002 study published in the Journal of Steroid Biochemistry and Molecular Biology closely investigated the effects of these free fatty acids on the two sub-types of 5-alpha reductase.

The researchers used an extract of saw palmetto, a herb with a very high content of free fatty acids and found that this extract was effective against both type 1 and type 2 5-alpha reductase.

By being active against both types of 5-alpha-reductase, Revivogen provides a broader spectrum of activity than most hair loss products with a similar mechanism of action. It is, therefore, more effective than hair loss products that can block only one of the enzyme types.

Azelaic acid, Zinc, and Vitamin B6

Azelaic acid is a phytochemical and an anti-inflammatory agent. Although it is most commonly known as an acne remedy, it can also help stop hair loss.

Azelaic acid also works by blocking DHT. In a 2005 study published in the American Journal of Clinical Dermatology, azelaic acid was compared to anthralin for effectiveness in the treatment of hair loss.

Of the 31 participants (suffering from patchy alopecia areata) recruited for this study, 15 were given 20% azelaic acid cream while 16 got 0.5% anthralin cream. After 12 weeks of use, an 8-week washout period was allowed during which no topical hair loss products were given.

The results of the study showed that both azelaic acid and anthralin were effective and that their efficacies were comparable.

After 20 weeks, more than half of the participants fully responded to azelaic acid or anthralin.

A 1998 study published in the British Journal of Dermatology investigated the inhibitory effects of zinc and azelaic acid on 5-alpha reductase. The result of this study showed that the combination of zinc and azelaic acid was more effective at preventing hair loss than zinc or azelaic acid alone.

The study also showed that the addition of vitamin B6 improved the activity of zinc against 5-alpha-reductase but not the activity of azelaic acid.

Lastly, the combination of low doses of all 3 hair loss remedies produced 90% inhibition of this enzyme.

Zinc can promote hair regrowth by other means that involves lengthening the growth phase and shortening the resting and hair loss phases of the hair growth cycle. Furthermore, zinc deficiency is common among people suffering from alopecia.


Beta-sitosterol is a plant sterol whose chemical structure is similar to cholesterol. It is commonly used to lower blood cholesterol levels.

However, beta-sitosterol is also an effective hair loss remedy. It also works by blocking 5-alpha-reductase from converting testosterone to DHT.

In a 2002 pilot study published in the Journal of Alternative and Complementary Medicine, the combination of beta-sitosterol and saw palmetto extract stopped hair loss and stimulated the growth of new hair in 60% of a group of participants suffering from alopecia areata.

Saw Palmetto

Saw palmetto or Serenoa repens is the most studied herb in hair loss treatment.

This herb is rich in free fatty acids including 4 fatty acids discussed above. It is also an excellent source of plant sterols including beta-sitosterol. Therefore, saw palmetto provides multiple ways of inhibiting 5-alpha reductase.

Besides hair loss, saw palmetto is also used in the treatment of benign prostatic hyperplasia and polycystic ovarian syndrome. In fact, the conversion of testosterone to DHT contributes greatly to the appearance and progression of these two medical conditions.


The oligomeric proanthocyanidins in Revivogen are common ingredients of hair loss products. They are better antioxidants than vitamins C and E.

As a hair loss remedy, proanthocyanidins are called nature’s minoxidil (the first FDA-approved hair loss medication and the active ingredient of Rogaine). This is because they turn the telogen (resting) phase of the hair growth cycle into a second anagen (growth spurt) phase.





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