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Viaprene Supplement Facts

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Learn more about the ingredients in Viaprene.


 Viaprene Supplement Facts

 Serving Size:  1 Capsule
 Servings Per Container:  30

Per Serving
Daily Value

  Vitamin B2 (Riboflavin) 200 mg 11764%

  Magnesium (Oxide)

50 mg


  Feverfew Extract (leaf) Tanacetum parthenium

50 mg *

  5-Hydroxytryptophan (5-HTP) 25 mg *

  Co-Enzyme Q10 75 mg *

 *Daily Value Not Established


Daily Dosage:As a dietary supplement, take one capsule in the morning with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.


Viaprene Research:

Feverfew (Tanacetum parthenium)- This medicinal plant contains parthenolide, an active ingredient which can be quite beneficial to patients suffering from migraines. A double-blind, placebo-controlled trial showed that patients who took feverfew for four months experienced a reduction in the mean number and severity of attacks, the degree of vomiting and visual analog scores were significantly improved without the incidence of serious side-effects (1).

Another trial showed that four months of feverfew supplementation reduced the number of attacks from 4.79 per month to 1.9 per month (2). Feverfew is also effective in treating a migraine attack and when taken in the mild pain phase, 48% of subjects were pain-free within two hours (3). A systematic review of trials concluded that feverfew is an effective and safe preventative treatment for migraines (4).

Magnesium- Mitochondrial metabolism may play a role in migraines, and supplements like magnesium which influence the mitochondria have shown effectiveness in some clinical trials (5). An analysis of evidence-based information concluded that magnesium is an effective prophylactic treatment for a migraine (6).

In children, oral magnesium treatment can significantly reduce the number of headache days (7). A clinical study showed that magnesium was superior to placebo in treating migrainous aura at 30 and 60 minutes after administration (8). Magnesium levels measured in white blood cells are significantly lower in patients with recurrent migraines when compared to healthy controls (9).

Riboflavin (Vitamin B-2)- Also important for mitochondrial function, riboflavin has been shown to reduce the incidence of migraines. An open trial demonstrated that supplementation with riboflavin for 3 months reduced the frequency of attacks from 4 to 2 days per month and significantly decreased the amount of abortive anti-migraine medications taken (15).

A randomized controlled trial showed that migraines were reduced at least 50% in frequency by 59% of patients who took riboflavin for three months (16). Riboflavin appears to work on a different pathway than beta-blocker medications that are prescribed for migraine sufferers (17).

Coenzyme Q10 (CoQ10)- Supplementation with Co Q10 may benefit migraine patients by enhancing mitochondrial function (18). An open-label trial of Co Q10 treatment showed that 61.3% of patients had a greater than 50% reduction in the number of days with a migraine headache (19).

A follow-up study demonstrated that CoQ10 was superior to placebo for attack frequency, headache-days, and days-with-nausea in the third treatment month and was well tolerated (20).


1. Murphy JJ, Heptinstall S, Mitchell JR. Randomized double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet 1988 Jul 23;2(8604):189-92.

2. Diener HC et al. Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study. Cephalalgia 2005 Nov;25(11):1031-41.

3. Cady RK et al. Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase. Med Sci Monit 2005 Sep;11(9):PI65-9. Epub 2005 Aug 26.

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Do you suddenly get throbbing sensations in your head? Try Viaprene, a natural remedy for severe headaches.