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Comparing Antidepressants

There are many drugs as well as natural supplements that may help you with depression. Depression can occur if the brain is not functioning properly. If the neurotransmitters are not doing what they are meant to do it can cause depression.

The three main neurotransmitters involved in depression are dopamine, norepinephrine, and serotonin. When brain levels of one or more neurotransmitter are low or unbalanced, depression and other conditions can result. Generally, antidepressant drugs work by increasing the production or decreasing the breakdown of one or more neurotransmitter.

 

Serotonin Reuptake Inhibitors

Currently the most prescribed type of antidepressants in the U.S., selective serotonin reuptake inhibitors primarily affect serotonin levels, Serotonin may influence mood more than the other neurotransmitters do. Abnormally low levels of serotonin not only play a role in depression; they also contribute to other conditions such as eating disorders, obsessive-compulsive disorder, panic disorder, and social anxiety disorder. By blocking the bodys reabsorption of serotonin and possibly increasing serotonin release, SSRIs keep more serotonin in the brain.

There are several kinds of antidepressants available and everyone reacts differently to the different classes of medications. The choice of an antidepressant depends on factors that include:

  • type of depression being treated
  • doctor's experience
  • other medical conditions the patient may have
  • other medications the patient takes
  • patients response to previous therapy
  • patients prescription formulary

Deciding which SSRI (selective serotonin reuptake inhibitors) to use first generally depends on the doctor's experience, the specific type of depression being treated, the patients response to previous therapy, other medical conditions the patient may have, and other medications the patient takes.

Drugs in this class include:

  • citalopram (Celexa, Cipramil, Dalsan, Emocal, Sepram, Seropram)
    • Citalopram is an antidepressant drug used to treat major depression associated with mood disorders. It is also used on occasion in the treatment of body dysmorphic disorder and anxiety.
  • escitalopram (Lexapro, Cipralex, Esertia)
    • Escitalopram (trade names Lexapro, Cipralex) is the pure enantiomer of citalopram and is a selective serotonin reuptake inhibitor (SSRI). It is approved for the treatment of major depressive disorder and generalized anxiety disorder; other indications include social anxiety disorder, panic disorder and obsessive-compulsive disorder. Escitalopram is noted for its high selectivity of serotonin reuptake inhibition and, as a result has fewer side effects not related to its serotonergic activity. Escitalopram acts by increasing intrasynaptic levels of the neurotransmitter serotonin by blocking the reuptake of the neurotransmitter into the neuron.
  • fluoxetine (Prozac, Fontex, Seromex, Seronil, Sarafem, Fluctin (EUR), Fluox (NZ), Depress (UZB))
    • Fluoxetine is approved for the treatment of major depression (including pediatric depression), obsessive-compulsive disorder (in both adult and pediatric populations), bulimia nervosa, anorexia nervosa, panic disorder and premenstrual dysphoric disorder.
  • fluvoxamine (Luvox, Fevarin, Dumyrox, Favoxil, Movox)
    • Fluvoxamine (Luvox) is an antidepressant which functions as a selective serotonin reuptake inhibitor. It is most often used to treat obsessive-compulsive disorder. Fluvoxamine is widely prescribed to treat major depression, and anxiety disorders such as Obsessive-Compulsive Disorder, Obsessive-Compulsive Spectrum Disorder, Panic Disorder, Social Phobia, and Post-Traumatic Stress Disorder. Fluvoxamine is indicated for children and adolescents with OCD.
  • paroxetine (Paxil, Seroxat, Sereupin, Aropax, Deroxat, Rexetin, Xetanor, Paroxat)
    • Paroxetine is primarily used to treat the symptoms of major depression, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), panic disorder, generalized anxiety disorder (GAD), social phobia/social anxiety disorder, and premenstrual dysphoric disorder (PMDD). It was the first antidepressant formally approved in the United States for the treatment of panic attacks. The prescription of this drug is controversial because of side effects such as suicidal ideation (thoughts of suicide) and withdrawal syndrome which have resulted in legal proceedings against the manufacturer.
  • sertraline (Zoloft, Lustral, Serlain)
    • Sertraline is primarily used to treat major depression in adult outpatients as well as obsessive-compulsive, panic and social anxiety disorders in both adults and children. Sertraline is highly effective for the treatment of panic disorder, but cognitive behavioral therapy is a better treatment for obsessive-compulsive disorder, whether by itself or in combination with sertraline. Although approved for social phobia and posttraumatic stress disorder, sertraline leads to only modest improvement in these conditions. Sertraline also alleviates the symptoms of premenstrual dysphoric disorder and can be used in sub-therapeutic doses or intermittently for its treatment.

The main indication for SSRIs is clinical depression. SSRIs are frequently prescribed for anxiety disorders like social anxiety, panic disorders, obsessive-compulsive disorder (OCD), eating disorders, chronic pain, and occasionally for Posttraumatic stress disorder (PTSD).

Though not specifically indicated by the manufacturers, they are sometimes prescribed to treat irritable bowel syndrome (IBS), Lichen simplex chronicus, and premature ejaculation.

Almost all SSRIs are known to cause one or more of these symptoms:

  • nausea
  • drowsiness
  • headache
  • clenching of teeth
  • extremely vivid and strange dreams
  • dizziness
  • changes in appetite
  • weight loss/gain
  • may result in a double risk of bone fractures and injuries
  • changes in sexual behavior
  • increased feelings of depression and anxiety
  • tremors
  • liver or renal impairment
  • suicidal ideation (thoughts of suicide)
  • Photosensitivity (increased risk of sunburn) (Use protective clothing, such as long sleeves and hats, and sunscreen to decrease the risk of sunburn.)

 

Natural Supplement for Depression - Exulin

The goal of Exulin is to assist in the removal of symptoms associated with your depression and to help you return to what you construe as a normal way of life. Depression is a serious condition that should be managed like any other major disease condition. And like major illnesses, the longer you avoid treatment, the more difficult depression is to treat.

Exulin is a unique alternative therapy. Not only are its ingredients all natural, studies indicate that the ingredients found in this comprehensive formula are extremely effective at maximizing your body's natural production of serotonin.

A few ingredients in Exulin are:

  • L-Phenylalanine - This amino acid is required for the production of neurotransmitters.
  • Rhodiola Rosea Ext. - This botanical's chemical constituents aid in transporting nutrients to the brain; including tryptophan, 5-HTP, and serotonin. In addition, Rhodiola may be helpful for decreasing the enzymes that break down serotonin.
  • Vitamin B6 - B-vitamin compounds are important for the conversion of tryptophan into serotonin. Deficiencies in vitamin B6 have been associated with depression and anxiety.
  • Folic Acid - Doctors at the Department of Psychiatry at Harvard Medical School suggest that depressive symptoms can be a sign of an underlying folic acid deficiency.
  • Gingko Biloba Ext. - Often used in combination with St. John's Wort to help with severe cases of depression, this popular herb improves circulation throughout the body, including the brain.

For a complete list of ingredients Click Here.

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