Medonin Supplement Facts

Other Ingredients:Gelatin,Rice Powder, Magnesium Stearate

Daily Dosage: As a dietary supplement, take one capsule in the morning and one capsule in the afternoon with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.

Medonin Research:

Cranberry- Regular use of cranberry juice significantly reduces bacterial growth in the urinary tract, and improves the body's response to infection in the form of white blood cells. One double-blind, placebo controlled study, published in the Journal of the American Medical Association, found that supplementation with cranberry juice significantly reduced the frequency of bacteria and pus in the urine of older women with recurrent urinary tract infections (1-7).

Blueberry (Vaccinium angustifolium) – Blueberry contains similar components as cranberry. Like cranberry, blueberry appears to prevent bacterial adhesion to the lining of the urinary bladder and bacterial colonization. (7)
**blueberry is often confused with bilberry. Blueberry in the US refers to the species of Vaccinium listed here. However, elsewhere in the world, blueberry may refer to the European plant, Vaccinium myrtillus, which is called bilberry in the US.

D-Mannose - Mannose is a natural occurring simple sugar that is helpful in treating urinary tract infections. Research suggests that d-mannose binds to bacteria that cause urinary tract infections (UTIs) and may therefore help prevent UTIs. (8-9)

Uva-Ursi leaf (Arctostaphylos uva-ursi) – The herb urva-ursi has urinary antiseptic and astringent effects. Urva-ursi leaf extract is approved in Germany for treatment of bladder infections. Urva-ursi’s active constituent, arbutin, is converted to hydroquinone in the urine, which kills bacteria. (10-12)

Probiotics (acidophilus) – Probiotic beneficial bacteria may involve anti-adhesion factors and create by-products that kill bacterial pathogens, possibly modulating immune signaling effects. In mouse model studies of UTIs, researchers introduced specific strains of Lactobacillus intraurethrally and found that Lactobacillus worked as an effective treatment and preventive of UTIs. (13)

References:

1. Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA. 1994 Mar 9;271(10):751-4.

2. Stothers L. A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infections in women. Can J Urol. 2002 Jun; 9(3): 1558-1562.

3. Sobota AE. Inhibition of bacterial adherence by cranberry juice: Potential use for the treatment of urinary tract infections. J Urol 1984;131:1013–6.

4. Dignam R, Ahmed M, Denman S, et al. The effect of cranberry juice on UTI rates in a long term care facility. J Am Geriatr Soc 1997;45:S53.

5. Walker EB, Barney DP, Mickelsen JN, et al. Cranberry concentrate: UTI prophylaxis. J Family Pract 1997;45:167–8 [letter].

6. Schlager TA, Anderson S, Trudell J, Hendley JO. Effect of cranberry juice on bacteriuria in children with neurogenic bladder receiving intermittent catheterization. J Pediatr 1999;135:698–702.

7. Ofek I, Goldhar J, Zafriri D, et al. Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. N Engl J Med 1991;324:1599.

8. Ofek I, Goldhar J, Esltdat Y, Sharon N. The importance of mannose specific adhesins (lectins) in infections caused by Escherichia coli. Scand J Infect Dis Suppl 1982;33:61–7.

9. Toyota S, Fukushi Y, Katoh S, et al. Anti-bacterial defense mechanism of the urinary bladder. Role of mannose in urine. Nippon Hinyokika Gakkai Zasshi 1989;80:1816–23 [in Japanese].

10. Larsson B, Jonasson A, Fianu S. Prophylactic effect of UVA-E in women with recurrent cystitis: a preliminary report. Curr Ther Res 1993;53:441-3.

11. Yarnell E. Botanical medicines for the urinary tract. World J Urol. 2002 Nov; 20(5): 285-293.

12. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 224–5.

13. Asahara T, Nomoto K, Watanuki M, Yokokura T. Antimicrobial activity of intraurethrally administered probiotic Lactobacillus casei in a murine model of Escherichia coli urinary tract infection. Antimicrob Agents Chemother. 2001 Jun;45(6):1751-60.