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B12 and Restless Leg Syndrome

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Although there are only a handful of studies done on the link between vitamin B12 and restless leg syndrome, the vitamin is a great supplement to help improve iron levels and protect nerve cells. Find out how vitamin B12 is the best vitamin to help supplement the management of restless leg syndrome.

What is Vitamin B12?

Vitamin B12 is also called cobalamin. This water-soluble B vitamin is involved in many cellular processes including metabolism, DNA synthesis, and energy production.

Vitamin B12 is the most complex vitamin and it is the only one to contain a rare element (cobalt).

There are 4 known forms of vitamin B12. First, there is cyanocobalamin which is the form contained in most vitamin B12 supplements. It is produced from hydroxocobalamin, the form of the vitamin produced by bacteria. During the process of purifying hydroxocobalamin with activated charcoal, it picks up cyanide to form cyanocobalamin.

The second form of vitamin B12 is hydroxocobalamin which is also produced by bacteria.

The other two forms of vitamin B12 are methylcobalamin and adenosylcobalamin. These are the forms of the vitamin produced in humans.

Dietary sources of vitamin B12 include plants and animals that have native bacteria producing the vitamin. Plants are not excellent sources of vitamin B12 since those bacteria are found in soils or roots and most of the vitamin B12 content is washed off before or during cooking.

Animal liver is an especially excellent source of vitamin B12. Other animal sources of the vitamin are fish, shellfish, egg, milk, milk products, and poultry.

Vitamin B12 is also sometimes added to food and drink products especially energy drinks. They are also available as supplements in different dosage forms.

The recommended daily intake of vitamin B12 is 2 – 3 micrograms per day.

Vitamin B12 deficiency can cause extensive damage to the brain and central nervous system. Even a mild deficiency of vitamin B12 causes depression, tiredness, and poor memory. More extensive and permanent damage to the brain is caused by chronic vitamin B12 deficiency.

Vitamin B12 deficiency is mostly caused by pernicious anemia. Since anemia is also linked with iron deficiency (through the loss of heme iron from the body), this vitamin is indirectly linked to disorders caused by iron deficiency such as restless leg syndrome.

Restless Leg Syndrome and Vitamin B12

How Vitamin B12 Deficiency May Cause Restless Leg Syndrome

Vitamin B12 deficiency may contribute to restless leg syndrome in 2 ways.

First, this deficiency can cause significant damage to the central nervous system including in the brain. Damage can occur in the parts of the brain regulating motor functions.

Since restless leg syndrome is essentially caused by improper coordination, control, and inhibition of excessive movement, damage to the neurons responsible for these functions may cause symptoms resembling restless leg symptoms.

Such damage does not have to be cell deaths in the brain. It may well be that vitamin B12 deficiency leads to the production of dysfunctional enzymes and surface proteins such as the ones known to prevent the absorption of iron into the cells of the substantia nigra.

A low iron level in the cerebrospinal fluid is one of the major diagnostic signs of restless leg syndrome.

Iron is needed to produce dopamine which is the chief neurotransmitter for regulating the coordination of fine motor function such as limb movements. Since vitamin B12 is closely linked to iron levels in the body, vitamin deficiency is often seen along with iron deficiency.

Anemia causes both the loss of iron and vitamin B12. Therefore, where anemia is the cause of restless leg syndrome, vitamin B12 supplementation is especially important for treating the anemia, preventing further iron loss, and overcoming the deficiencies that cause restless leg syndrome.

Vitamin B12 deficiency is only a secondary cause of restless leg syndrome.

It has not been directly linked to the syndrome even though there are a few recorded cases of patients with this deficiency.

However, given the increased incidence of iron deficiency and the strong association between both deficiencies, vitamin B12 does not feature prominently in the research and treatment of restless leg syndrome.

Of the few papers written on the topic, the 1993 study published in the Journal of Postgraduate Medicine stands out.

This study accessed the prevalence of restless leg syndrome among elderly patients and noted both iron and vitamin B12 deficiencies as common and treatable causes of the syndrome.

In fact, in the few patients where marked vitamin B12 deficiency was known to cause restless leg syndrome, a complete resolution of symptoms was observed 1 month after starting on vitamin B12 supplementation.

How to Take Vitamin B12 for Restless Leg Syndrome

Up to 1000 micrograms per day are recommended to correct severe vitamin B12 deficiency before reducing the dose to 2.5 micrograms per day. However, such severe deficiency would need hospitalization in the first place.

Vitamin B12 supplements are available in different dosage forms including oral, sublingual, nasal spray, and injectable forms.

Absorption following oral intake of vitamin B12 is low, therefore, the strength of the vitamin taken far exceeds the recommended daily intake.

Since vitamin B12 supplementation would not be sufficient to treat most restless leg syndrome patients, it is best to take this vitamin along with other natural supplements including vitamins, minerals, amino acids, and herbal extracts; which are known to improve the symptoms of restless leg syndrome.

Such a combination of supplement provides a broader spectrum of action. For example, combining iron and vitamin B12 is a good way to treat anemia along with restless leg syndrome.

A good example of natural supplements with this combination is Sedorum.

Sedorum not only contains vitamin B12 and iron but also folic acid (folate deficiency is linked to both iron and vitamin B12 deficiencies and it is common in restless leg syndrome patients), magnesium (magnesium deficiency is also a known cause of restless leg syndrome), calcium, glycine, GABA, valerian extract and lemon balm extract.





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