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Sedorum Supplement Facts

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Learn more about the ingredients in the restless leg supplement Sedorum.

 Sedorum Supplement Facts  

 Serving Size:  4 Capsules
 Servings Per Container:  30

Per Serving
Daily Value

  Folic Acid 5000 mcg 1250%

  Vitamin B12 (Cyanocobalamin) 25 mcg 416%

  Calcium (as Calcium Gluconate) 50 mg 5%

  Iron (as Amino Acid Chelate) 25 mg 139%

  Magnesium (as Magnesium Oxide) 175 mg 44%

  Valerian Extract (Valeriana officinalis) (root) 250 mg *

  Lemon Balm Extract (Melissa officinalis) (leaf) 50 mg *

  GABA Powder 1500 mg *

  Glycine 500 mg *

   Other Ingredients:  Vegetarian Capsule (Hypromellose), Rice Powder, Magnesium Stearate.
   *Daily Value Not Established

Daily Dosage: As a restless leg dietary supplement, take two capsules in the morning and two capsules in the evening with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.


Sedorum Research:

Folic Acid - Reports exist of folic acid reducing symptoms associated with restless leg syndrome (RLS) such as numbness, cramps, and paresthesias (1). Pregnant women have a two to three times increased risk of developing RLS possibly due to deficiency of folic acid and iron (2). One study showed that reduced serum folic acid levels were correlated with restless legs syndrome in pregnancy and supplementation could minimize these symptoms and promote better sleep (3).

Vitamin B12 - A study of nearly 800 seniors showed that vitamin B12 deficiency is common in subjects with neurosensory deficits and RLS (4). There are some preliminary clinical reports that the cyanocobalamin form of vitamin B12 can help relieve tremors associated with restless leg syndrome (5).

Iron - Low levels of iron are associated with RLS in elderly populations, but occasionally plasma levels may not reflect a deficiency while bone marrow measurements can (6,7). A clinical study showed that treatment with iron supplements for 2 months significantly improved the RLS severity score (7). Research suggests abnormal brain iron metabolism plays a role in dopaminergic systems in the brain, influencing the circadian pattern of RLS, and interfering with sleep (8-10).

Magnesium and Calcium - Supplementation with magnesium may be useful for treating restless legs syndrome. In some RLS patients, magnesium treatment may decrease the amount of movement and increase the amount of sleep in mild to moderate cases (11). Magnesium deficiency in patients with RLS demonstrates changes in the EEG patterns observed in sleep such as decreased duration and percentage of restorative REM sleep (12). Calcium, an essential mineral, is required for optimal absorption and effectiveness of magnesium and contributes to normalized brain and neurological function. Typically, these two should be supplemented together in a 2:1 ratio.

Valerian - Valerian root is commonly used for sleeping disorders (RLS is classified as a sleep disorder) due to its sedative-hypnotic and anxiolytic effects. A double-blind, placebo-controlled study of patients who took a combination of valerian and lemon balm demonstrated amelioration of negative effects of induced stress (13). A randomized, placebo-controlled trial conducted at multiple centers showed that a combination of valerian and hops has moderate hypnotic effects, improving sleep and quality of life safely without causing a rebound of sleep problems with discontinuation of treatment (14).

Lemon balm (Melissa officinalis) - Animal research provides evidence that lemon balm produces peripheral pain relief and can act as a sedative-hypnotic agent (15). Combined with valerian, lemon balm can improve the quality and quantity of sleep (16). As well, EEG research on a lozenge containing lemon balm demonstrated anxiolytic effects suggesting it could better help cope with emotional and physiological stress (17).

GABA (Gamma Amino Butyric Acid) - GABA is the primary inhibitory neurotransmitter in the central nervous system. Gabapentin, a structural analog of GABA, is a conventional drug that in clinical trials has shown effectiveness in reducing sensory and motor symptoms of RLS and improving sleep-related difficulties (18,19).

Glycine - Research is showing that glycine acts as a neurotransmitter and plays a central role in regulating motor reflexes and nociceptive pathways (20). The anticonvulsant drug diazepam exerts its effects through interaction with GABA and glycine receptors, and the addition of glycine results in increased anticonvulsant effects in animals (21).

Sedorum References:

  1. Botez MI, Cadotte M, Beaulieu R, et al. Neurologic disorders responsive to folic acid therapy. Can Med Assoc J 1976;115:217-23.

  2. Manconi M et al. Pregnancy as a risk factor for restless legs syndrome. Sleep Med 2004 May;5(3):305-8.

  3. Lee KA et al. Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron. J Women's Health Gend Based Med 2001 May;10(4):335-41.

  4. Mold JW et al. The prevalence, predictors, and consequences of peripheral sensory neuropathy in older patients. J Am Board Fam Pract 2004 Sep-Oct;17(5):309-18.

  5. Benito-Leon J, Porta-Etessam J. Shaky-leg syndrome and vitamin B12 deficiency. N Engl J Med 2000;342:981.

  6. O'Keeffe ST. Secondary causes of restless legs syndrome in older people. Age Ageing. 2005 Jul;34(4):349-52. Epub 2005 May 10.

  7. O'Keeffe ST, Gavin K, Lavan JN. Iron status and restless legs syndrome in the elderly. Age Ageing 1994 May;23(3):200-3.

  8. Barriere G et al. The restless legs syndrome. Prog Neurobiol 2005 Oct;77(3):139-65. Epub 2005 Nov 21.

  9. Thorpy MJ. New paradigms in the treatment of restless legs syndrome. Neurology 2005 Jun 28;64(12 Suppl 3):S28-33.

  10. Allen R. Dopamine and iron in the pathophysiology of restless legs syndrome (RLS). Sleep Med 2004 Jul;5(4):385-91.

  11. Hornyak M et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep 1998 Aug 1;21(5):501-5.

  12. Popoviciu L et al. Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency. Rom J Neurol Psychiatry 1993 Jan-Mar;31(1):55-61.

  13. Kennedy DO et al. Anxiolytic effects of a combination of Melissa Officinalis and Valeriana Officinalis during laboratory-induced stress. Phytother Res 2006 Feb;20(2):96-102.
  14. Morin CM et al. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep 2005 Nov 1;28(11):1465-71.

  15. Soulimani R et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med 1991 Apr;57(2):105-9.

  16. Cerny A, Shmid K. Tolerability and efficacy of valerian/lemon balm in healthy volunteers (a double-blind, placebo-controlled, multicentre study). Fitoterapia 1999;70:221-8.

  17. Dimpfel W, Pischel I, Lehnfeld R. Effects of lozenge containing lavender oil, extracts from hops, lemon balm, and oat on the electrical brain activity of volunteers. Eur J Med Res 2004 Sep 29;9(9):423-31.

  18. Garcia-Borreguero D et al. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Neurology 2002 Nov 26;59(10):1573-9.

  19. Happe S et al. Gabapentin versus ropinirole in the treatment of idiopathic restless legs syndrome. Neuropsychobiology 2003;48(2):82-6.

  20. Bowery NG, Smart TG. GABA and glycine as neurotransmitters: a brief history. Br J Pharmacol 2006 Jan;147 Suppl 1: S109-19.

  21. Sangiah S. Effects of glycine and other inhibitory amino acid neurotransmitters on strychnine convulsive threshold in mice. Vet Hum Toxicol 1985 Apr;27(2):97-9.