Avistate Supplement Facts

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Learn more about the ingredients in Avistate.

Serving Size: 1 Capsule
Servings Per Container: 30

Amount
Per Serving

Daily Value

Selenium (as Selenomethionine)

25 mcg

35%

Saw Palmetto Extract (Serenoa repens) (berry)

80 mg

Pygeum Extract (Pygeum Africanum) (bark)

50 mg

Nettle Extract (Urtica dioica) (root)

25 mg

Soy Extract
Isoflavones 25 MG

62.5 mg

Lycopene

5 mg

Other Ingredients: Vegetarian Capsule (Hypromellose), Rice Powder, Magnesium Stearate.
*Daily Value Not Established

Daily Dosage: As a dietary supplement, take one capsule in the morning with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.

Avistate Research:

Serenoa repens (Saw Palmetto)- Saw palmetto is an effective treatment for benign prostatic hyperplasia (BPH). Several clinical studies have shown significant improvement in lower urinary tract symptoms (LUTS) like frequent urination, painful urination, hesitancy, urgency, and perineal heaviness (1-3).

It also decreases nocturia, improves peak and mean urinary flow, and lowers residual urine volume in patients with BPH. A recent study showed that unlike the pharmaceutical medications, Tamsulosin and Finasteride, Saw palmetto had no negative side effects on sexual function (4).

Saw palmetto appears to have a number of effects including, antiandrogenic action, an anti-inflammatory effect and an antiproliferative influence through the inhibition of growth factors (5). This herbal extract is safe and effective even in cases with moderate and severe symptoms (6).

It has even demonstrated superior effectiveness over conventional medications for BPH, without the bothersome side effects and is less expensive (7). Saw palmetto can also decrease complications and improve the efficacy of the surgical procedure, transurethral resection of the prostate (TURP) (8).

Pygeum africanum (Pygeum bark) - A review of current studies on pygeum for BPH suggests this botanical medicine is also an effective and safe treatment, improving both urological symptoms and measurements of flow (9).

In double-blind controlled studies, dosage levels of 100mg daily have proven effective and safe to take long-term (10). Like Serenoa treatment, negative sexual side effects are absent (11). Pygeum inhibits cell growth of prostate cancer and hyperplastic cell lines (12,13).

Urtica dioica (Nettle root) - Urtica is another safe and effective herbal treatment for BPH. Placebo-controlled studies have demonstrated its effectiveness even in moderate and severe cases (6). Urtica has similar effectiveness to finasteride, a pharmaceutical medication, but is much better tolerated (14).

It may work through an antiproliferative effect on prostatic cells and may also lessen the effects of androgenic hormones by competitively blocking access to human sex hormone binding globulin (SHBG) (15,16). Urtica extracts have also demonstrated anti-cancer activity in prostate cancer cell lines (15,17).

Isoflavones (soy extract)- Epidemiological studies show that diets higher in soy products are associated with reduced risk and progression of prostate cancer and prostatitis (18-20).

The isoflavone, genistein, appears to be involved in the pathogenesis of BPH and prostate cancer (21,22). Data suggests that supplementing early-stage prostate cancer patients with soy isoflavones, for as little as 12 weeks, can alter markers of proliferation like serum PSA and free testosterone (23).

Lycopene - Lycopene is beneficial for both prevention and treatment of prostate cancer. Men who consume 6 mg per day or more of lycopene from foods such as tomatoes and tomato products seem to have a significantly reduced risk of developing prostate cancer (24,25).

In patients with hormone-refractory metastatic prostate cancer, lycopene therapy can improve lower urinary tract symptoms, bone pain, and rising PSA and ECOG performance (26). It also improves the survival rate of orchidectomy in advanced metastatic prostate cancer and decreases the rate of growth of prostate cancer when given before radical prostatectomy (27,28).

Selenium- Increased intake of dietary selenium seems to reduce the risk of prostate cancer and slows the progression of tumor growth (29,30). Serum levels of selenium appear to be lower in patients with prostate cancer.

A large-scale trial called SELECT is currently underway to investigate the effects of the antioxidants, selenium and vitamin E, on the prevention of prostate cancer (31).

Sources

1. Boyle P et al. Updated meta-analysis of clinical trials of Serenoa repens extract in the treatment of symptomatic benign prostatic hyperplasia. BJU 2004 Apr;93(6):751-6.  

2. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9.  

3. Gordon AE, Shaughnessy AF. Saw palmetto for prostate disorders. Am Fam Phys 2003 Mar 15;67(6):1281-3.  

4. Zlotta AR et al. Evaluation of male sexual function in patients with Lower Urinary Tract Symptoms (LUTS) associated with Benign Prostatic Hyperplasia (BPH) treated with a phytotherapeutic agent (Permixon), Tamsulosin or Finasteride. Eur Urol 2005 Aug;48(2):269-76. Epub 2005 Apr 18.  

5. Buck AC. Is there a scientific basis for the therapeutic effects of serenoa repens in benign prostatic hyperplasia? Mechanisms of action. J Uorl 2004 Nov;172(5 Pt 1):1792-9  

6. Lopatkin N et al. Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms--a placebo-controlled, double-blind, multicenter trial. World J Urol 2005 Jun;23(2):139-46. Epub 2005 Jun 1.   

7. Debrunye F et al . [Evaluation of the clinical benefit of Permixon and tamsulosin in severe BPH patients--PERMAL study subset analysis] Prog Urol 2004 Jun;14(3):326-31  

8. Pecoraro S et al. [Efficacy of pretreatment with Serenoa repens on bleeding associated with transurethral resection of prostate] Minerva Urol Nefrol 2004 Mar;56(1):73-8.  

9. Wilt T et al. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev 2002;(1):CD001044.  

10. Chatelain C, Autet W, Brackman F. Comparison of once and twice daily dosage forms of Pygeum africanum extract in patients with benign prostatic hyperplasia: a randomized, double-blind study, with long-term open label extension. Urology 1999 Sep;54(3):473-8.  

11. Breza J et al. Efficacy and acceptability of tadenan (Pygeum africanum extract) in the treatment of benign prostatic hyperplasia (BPH): a multicentre trial in central Europe. Curr Med Res Opin 1998;14(3):127-39.  

12. Arch Esp Urol. Santa Maria Marhalef A et al. [Antimitogenic effect of Pygeum africanum extracts on human prostatic cancer cell lines and explants from benign prostatic hyperplasia] Arch Esp Urol 2003 May;56(4):369-78.  

13. Levin RM, Das AK. A scientific basis for the therapeutic effects of Pygeum africanum and Serenoa repens. Urol Res 2000;28:201-9.  

14. Combined sabal and urtica extract compared with finasteride in men with benign prostatic hyperplasia: analysis of prostate volume and therapeutic outcome. Sokeland J. BJU Int 2000 Sep;86(4):439-42.  

15. Konrad L, Muller HH, Lenz C, et al. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med 2000;66:44-7.   

16. Schottner M, Gansser D, Spiteller G, et al. Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Med 1997;63:529-32.  

17. Durak I et al. Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Cancer Biol Ther 2004 Sep;3(9):855-7. Epub 2004 Sep 18.  

18. Sonoda T, Nagata Y, Mori M, et al. A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet. Cancer Sci 2004;95:238-42.  

19. Chan JM, Gann PH, Giovannucci EL. Role of diet in prostate cancer development and progression. J Clin Oncol 2005 Nov 10;23(32):8152-60.  

20. Sharma OP et al. Soy of dietary source plays a preventive role against the pathogenesis of prostatitis in rats. J Steroid Biochem Mol Biol 1992 Nov;43(6):557-64.  

21. Brossner C et al. Phytoestrogen tissue levels in benign prostatic hyperplasia and prostate cancer and their association with prostatic diseases. Urology 2004 Oct;64(4):707-11  

22. Geller J et al. Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate 1998 Feb 1;34(2):75-9.  

23. Kumar NB. The specific role of isoflavones in reducing prostate cancer risk. Prostate 2004 May 1;59(2):141-7.  

24. Giovannucci E, Rimm EB, Liu Y, et al. A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst 2002;94:391-8.  

25. Campbell JK et al. Tomato phytochemicals and prostate cancer ris J Nutr 2004 Dec;134(12 Suppl):3486S-3492S.  

26. Ansari MS, Gupta NP. Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer. Urol Oncol 2004 Sep-Oct;22(5):415-20.  

27. Ansari MS, Gupta NP. A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. BJU Int 2003 Sep;92(4):375-8; discussion 378.  

28. Kucuk O et al. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomarkers Prev 2001 Aug;10(8):861-8.  

29. Clark LC, Dalkin B, Krongrad A, et al. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br J Urol 1998;81:730-4.  

30. Li H et al. A prospective study of plasma selenium levels and prostate cancer risk. J Natl Cancer Inst 2004 May 5;96(9):696-703.  

31. Pak RW et al. Review of vitamin E and selenium in the prevention of prostate cancer: implications of the selenium and vitamin E chemoprevention trial. Integr Cancer Ther 2002 Dec;1(4):338-44.

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